The size of conformational ensembles required for regular coverage of the conformational space of druglike molecules was examined. Using the conformer generation program Omega, the number of regularly distributed conformers (NRC) of flexible compounds was determined as a function of the root-mean-square deviation (RMSD) resolution of coverage. A regression equation was developed predicting the ...

A set of perception experiments, using reiterant speech, were designed to carry out a diagnostic of the segmentation / hierarchisation linguistic function of prosody. The prosodic parameters of F0, syllabic duration and intensity of the stimuli used during this experiment were extracted. Several dissimilarity measures (Correlation, root-mean-square distance and mutual information) were used to ...

This paper introduces a new method for the calibration of a range camera based on active triangulation. The technique is based on a model derived from the geometry of the synchronized scanner. From known positions of a calibration bar, a logistic equation is tted with values of spot positions read from a linear position detector at a number of angular positions of a scanning mirror. Furthermore...

BACKGROUND AND PURPOSE In selected patients undergoing epilepsy surgery, subdural electrode grids play an important role in localizing the epileptogenic zone and identifying eloquent cortex. Determining the relationship of the electrodes to underlying brain architecture traditionally has been difficult. This report describes and validates the use of an original computer-aided method that displa...

One of the troublesome aspects of numerical modeling is to determine open boundaries for a model and to make sure that the boundary conditions employed at the open boundaries are compatible with physical processes being simulated within the interior of the model domain. In this investigation the accuracy of the water level data derived from delft3D employing nesting procedure were studied. Thes...