نتایج جستجو برای: derived macrophages
تعداد نتایج: 541883 فیلتر نتایج به سال:
background: it has been shown that inhalation of carbonaceous particulate matter may impair lung function in children. objective: using the carbon content of airway macrophages as a marker of individual exposure to particulate matter derived from fossil fuel, we sought direct evidence for this association. methods: 300 children from puffed rice industrial areas and 300 children from population ...
nitric oxide (no) derived from activated macrophages has been shown to be crucial for the host's leishmanicidal activities. excess no, however, can in¬duce apoptosis in some cell types, including macrophages. in the present inves¬tigation, we studied the role of no in inducing apoptosis of balb/c mice mac¬rophages infected with leishmania major in vitro. the peritoneal macrophages were harveste...
BACKGROUND Antibodies are often involved in enhancing particle clearance by macrophages. Although the mechanisms of antibody-dependent phagocytosis have been studied for IgG in greater detail, very little is known about IgM-mediated clearance. It has been generally considered that IgM does not support phagocytosis. Recent studies indicate that natural IgM is important to clear microbes and othe...
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α response, viability, migration, phenotypic plasticity, metabolism macrophages. Specifically, macrophage-deriv...
ABSTRACT Host-derived antimicrobial peptides play an important role in the defense against extracellular bacterial infections. However, capacity of derived from macrophages as potential antibacterial effectors intracellular pathogens remains unknown. In this study, we report that normal (wild-type, WT) mouse increased their expression cathelin-related peptide (CRAMP, encoded by Camp) after infe...
Monocytes/macrophages are phagocytic innate immune cells playing a pivotal role in tissue homeostasis, inflammation, and antitumor immunity microenvironment-dependent manner. By expressing pattern recognition scavenger receptors on their surface, macrophages selectively take up pathogens, cellular debris, often—undesirably—drug delivery systems. On the other hand, propensity of to internalize p...
Abstract Helminth infection conditions lung macrophages in the long term, but little is known about how helminths affect macrophage responses to respiratory viral coinfection. Experimental helminth of BALB/c and C57BL/6 mice revealed an increased type 2 airway inflammation that was associated with pronounced phenotypic changes macrophages. These consist a disappearance reaction SiglecF+ alveola...
Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Duan Kaibo, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin,* and Muzlifah Han...
discussions in comparison to the control of wy14643, sandoz58-035, c9 and t11-cla, epa increased the pparα mrna levels (p = 0.024, p = 0.041, p = 0.043, and p = 0.004, respectively), even though, la had no significant effect on the pparα mrna expression (p = 0.489). materials and methods this experimental study investigated the effects of c9, t11-conjugated linoleic acid (c9, t11-cla). alpha li...
Abstract Kupffer cells (KCs) are the resident macrophages of liver with similar origins to myeloid-derived macrophages. Once differentiated, KCs exhibit distinct cellular machinery capable longevity and self-renewal, making them a crucial player in promoting effective intrahepatic communication. However, this gets compromised disease states like Nonalcoholic Steatohepatitis (NASH), where loss e...
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