irritable bowel syndrome (ibs) is the most prevalent functional gastrointestinal disorder noted in the general population worldwide. its chronic nature, signs and symptoms which vary periodically from mild to severe have many negative effects on the quality of life for the sufferer; therefore the appropriate treatment of these patients is highly important. patients should be informed by their d...

In the present study, the anti-depressant like effect of methyl gallate (MG) isolated from the stem bark of Acer barbinerve was examined in ICR mice. Body weight (BDW) and blood glucose (BDG) levels significantly decreased in the repeated restraint stress (RRS) group (2 h/day for 14 days) compared to the no stress (NS) group. To examine the effect of MG on RS-induced BDW loss and hypoglycemia, ...

objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...

introduction: depression has multifactorial characters including brain-behavioral disorders, alteration in cognitive psychomotor and emotional process. millions of people are worldwide suffering from this illness. this disease happens in all ages of men and women. this research tries to introduce a traditional medication in comparison with common chemical anti-depressant drugs. this experiment ...

Bekh-e-Karafs has been reported to be effective in a number of ailments in Unani system of medicine. The aqueous extract of the drug was screened for C.N.S. depressant, anti-convulsant and analgesic activities. The central depressant and analgesic activities of the drug were found to be significant while anti-convulsant activity was found to be insignificant. The results are reported here.

BACKGROUND Early discontinuation of anti-depressant treatment is common. This study analysed whether socio-economic factors influence early discontinuation among new anti-depressant users aged 20-34 years. METHODS Our study population included all Swedes aged 20-34 years who purchased anti-depressants in 2006 and had not purchased such drugs in the preceding 6 months (n = 25,003). We obtained...

Objective: The present work is designed to synthesise some isomeric new series of Quinazoline-4-one/4-thione derivatives, based on the pharmacophoric model of central nervous system (CNS) activity by structural modifications retaining the essential structural features for the activity and evaluated for their anticonvulsant and CNS depressant properties. Methods: A series of 7-chloro-3-[substitu...

BACKGROUND Collaborative care is a complex intervention based on chronic disease management models and is effective in the management of depression. However, there is still uncertainty about which components of collaborative care are effective. We used meta-regression to identify factors in collaborative care associated with improvement in patient outcomes (depressive symptoms) and the process ...

Myristica fatua var. magnifica (Beddome) Sinclair belongs to the family Myristicaceae. It is a tree used as an important plant to cure various diseases. In the present study the Petroleum ether, Ethyl acetate and Methanolic extracts of Myristica fatua was evaluated for its toxicity, potential analgesic, depressant and in vitro and in vivo anti-inflammatory activity. The extracts at different co...