The potency of nanoparticles, loaded with drugs, genes, and/or diagnostics, is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy is a powerful techniques to monitor the self-assembling of lipid-, polymer-, as well as protein/peptide-based drug and gene carries on a nano-size resolution scale. Freeze-fracture electron mic...

Los liposomas son vesículas artificiales biocompatibles y biodegradables que poseen una estructura con dos compartimentos capaces de albergar moléculas hidrofílicas lipofílicas, respectivamente. han sido ampliamente investigados durante los últimos veinte años como sistemas liberación fármacos, lo cual ha resultado en el desarrollo diversas tecnologías Stealth® DepoFoam®. Asimismo, surgido func...

Despite advances in drug technology and improvements in technology, including peripheral nerve catheters and ultrasound, postoperative pain is still a significant problem in the clinical setting worldwide. Postoperative pain can have a critical negative impact with regard to physiological consequences to the body and therefore, the role of liposomal bupivacaine as an extended release bupivacain...

The LMD of a systemic malignancy remains one of the greatest treatment challenges in cancer medicine (1). Few patients with this complication survive for more than a few months, and this outcome has not changed substantially over the past 20–30 years, despite the progress made in controlling cancer at most other sites in the body. Thus, any advance in the treatment of LMD, especially a modality...