In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially...

the whole plant of biophytum petersianum was extracted with a mixture of water – alcohol (1:1) to evaluate its relaxant effect on aorta rings. in isolated wistar rat tissue, the hydro-ethanolic extract (0.1; 0.25 and 0.5 mg/ml) non-competitively antagonized calcium chloride and high-k + - induced aorta contractions in a concentration-dependent manner. moreover, the inhibition of noradrenaline–i...

introduction: the functional effects of orexin-b on the calcium spikes and excitability of the neuronal soma membrane of garden snail, helix aspersa were studied. methods: conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-b on the configuration and electrophysiological properties of calcium spikes. results: application of ore...

In this study, the possible involvement of L-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. Addition of quercetin (0.1 µM-1 mM) caused a significant dose-dependent relaxation of noradrenaline (NA)- and KCl-preconstricted rings and nifedipine attenuated this response, especially...

Introduction: The functional effects of orexin-B on the calcium spikes and excitability of the neuronal soma membrane of garden snail, Helix aspersa were studied. Methods: Conventional intracellular recording, under the current clamp conditions was performed to examine the effects of orexin-B on the configuration and electrophysiological properties of calcium spikes. Results: Application o...

The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...

The primary mode of action of local anesthetics is through sodium channel and axonal conduction blockade. Local anesthetics have also extensive effects on pre-synaptic calcium channels that must function to stimulate the release of neurotransmitters. Thus, interference with calcium channel conductance may enhance spinal anesthesia with local anesthetics. The present study was designed to invest...