There are three mammalian, exclusively intramitochondrial, enzymes that, in mitochondrial extracts or aRer purification, are activated by Ca2+ with a k,, (concentration required for half-maximal effect) for Ca'+ of about 1 p ~ . These are pyruvate dehydrogenase phosphate phosphatase (Denton el al., 1972), ismitrate dehydrogenase (NAD+) (Denton et al., 1978) and the oxoglutarate dehydrogenase co...

Treatment of rat epididymal adipose tissue with insulin for a few minutes leads to a substantial increase in the rate of fatty acid synthesis, which is explained in part by rapid activation of the cytoplasmic enzyme acetyl-CoA carboxylase (Denton, 1975; Denton et al., 1977; Brownsey & Denton, 1979). The effects of insulin on fatty acid synthesis are opposed by adrenaline, but the changes in kin...

Induced Prophase Arrest in C. elegans Vinita A. Hajeri, Brent A. Little, Mary L. Ladage, Pamela A. Padilla* Department of Biological Sciences, University of North Texas, Denton TX 76203 Running Title: Prophase Arrest in C. elegans *Corresponding Author: P.A. Padilla, Department of Biological Sciences, University of North Texas, Denton TX 76203, Phone: (904) 565-3614, fax (940) 565-3821 ppadilla...

Luis A. Agapito, Stefano Curtarolo, and Marco Buongiorno Nardelli Department of Physics, University of North Texas, Denton, Texas 76203, USA Center for Materials Genomics, Duke University, Durham, North Carolina 27708, USA Materials Science, Electrical Engineering, Physics and Chemistry, Duke University, Durham, North Carolina 27708, USA Department of Physics and Department of Chemistry, Univer...

NAD+-isocitrate dehydrogenase (NAD+-ICDH) is one of three enzymes which catalyse the oxidation of threo-Ds-isocitrate to oxoglutarate and carbon dioxide in eukaryotic cells, the other two enzymes being the cytoplasmic and mitochondrial forms of NADP+-isocitrate dehydrogenase (NADP+-ICDH). NAD+ICDH is located within mitochondria and is a component of the citrate cycle. Although mitochondria from...

This review consists of a summary, criticism and conclusion of this now classic book. At first the title of this book withheld me from buying it. Crisis? I studied biology and specialised in genetics and evolution, but I never heard of a crisis in Darwinism. Yes, I noticed problems and controversies, the theory was incomplete, but crisis? Now I've got the book from a friend (1) and I read it. C...