MCT-1 is an oncogene that was initially identified in a human T cell lymphoma and has been shown to induce cell proliferation as well as activate survival-related pathways. MCT-1 contains the PUA domain, a recently described RNA-binding domain that is found in several tRNA and rRNA modification enzymes. Here, we established that MCT-1 protein interacts with the cap complex through its PUA domai...

The aim of the review was to investigate whether an assessment of clinical significance can be related to specific drug-related problems (DRPs) and hence may assist in prioritizing individual categories of DRP categorization systems. The literature search using Google Scholar was performed for the period 1990 to 2013 and comprised primary research studies of clinical pharmacy interventions incl...

This paper is devoted to the development of a theoretical and computational framework denominated dominant reaction pathways (DRPs) to efficiently sample the statistically significant thermally activated reaction pathways, in multidimensional systems. The DRP approach is consistently derived from the Langevin equation through a systematic expansion in the thermal energy, k(B)T. Its main advanta...

Many source and transport factors control P loss from agricultural landscapes; however, little information is available on how these factors are linked at a watershed scale. Thus, we investigated mechanisms controlling P release from soil and stream sediments in relation to storm and baseflow P concentrations at four flumes and in the channel of an agricultural watershed. Baseflow dissolved rea...

OBJECTIVE To assess the frequency and types of drug-related problems (DRPs) in patients seeking emergency care in a teaching hospital in southern Brazil and to identify the possible causes and drugs involved in these problems. METHOD A cross-sectional study was performed, using a structured questionnaire for data collection. Multivariate logistic regression was used to control for possible co...

DILL, L. M. 1978. Aggress~ve distance in juvenile coho salmon (Oncorhynchus kisutch). Can. J . Zool. 56: 14411446. The distances from which resident coho salmon approached, charged, or gave lateral displays to inhuders were recorded, as were rhe npproach and charge velocities. Ench of five residents was terted while under rhree Feeding t e ~ i m e ~ . and In response to three sizes of intnzder ...

We use the zone theorem for a better analysis of an algorithm for worst-case optimal convex decomposition of nOD·convex simple polyhedra. This new analysis reveals that the simple algorithm using repeated cutting and splitting through notches which guarantees a worst-case optimal convex decomposition is quite efficient. We establish an Denr + sr:!) time and an D(nr) space bound for the algorith...