BACKGROUND Dendroaspis natriuretic peptide (DNP), recently isolated from the venom of the green Mamba snake Dendroaspis angusticeps, is a 38 amino acid peptide containing a 17 amino acid disulfide ring structure similar to that of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). DNP-like immunoreactivity (DNP-LI) was reported to be present...

Jolkkonen, M., 1996. Muscarinic Toxins from Dendroaspis (Mamba) Venom: Peptides Selective for Subtypes of Muscarinic Acetylcholine Receptors. Acta Univ. Ups., Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 183. 52 pp. Uppsala. ISBN 91-554-3675-7 Snake venoms from various mamba species contain peptides which bind to the muscarinic but not to the nicot...

Animal venoms represent a valuable source of bioactive peptides that can be derived into useful pharmacological tools, or even innovative drugs. In this way, the venom of Dendroaspis angusticeps (DA), the Eastern Green Mamba, has been intensively studied during recent years. It mainly contains hundreds of large toxins from 6 to 9 kDa, each displaying several disulfide bridges. These toxins are ...

Prokineticin receptors, PKR1 and PKR2 (provisional nomenclature as recommended by NC-IUPHAR [26]) respond to the cysteine-rich 81-86 amino-acid peptides prokineticin-1 (also known endocrine gland-derived vascular endothelial growth factor, mambakine) prokineticin-2 (protein Bv8 homologue). An orthologue of PROK1 from black mamba (Dendroaspis polylepis) venom, intestinal toxin 1 (MIT1, [71]) is ...

We report a case of accidental green mamba (Dendroaspis viridis) envenomation in the suburbs of Paris. Although moderate, neurotoxic symptoms were clearly present. Immunotherapy with polyvalent serum FAV-Afrique was decided, but logistical problems prevented reasonably quick serum delivery to the hospital. Despite a spontaneously favourable outcome probably due to minimal envenomation, this cas...

Dendroaspis natriuretic peptide (DNP) is a recently described peptide produced by Dendroaspis angusticeps with structural and functional similarities to mammalian natriuretic peptides. These similarities suggest a potential role for DNP in cardiovascular therapeutics. To determine the physiological effects of chronic delivery of DNP, a gene transfer approach using first generation adenoviral ve...

A toxin, designated Fvrr has been isolated from the venom of the green mamba Dendroaspis angusticeps by ion exchange chromatography on Amberlite CG-50 and gel filtration on Sephadex G-50. . Toxin FvII consists of 61 amino acid residues, is devoid of phenylalanine and tryptophan, and is cross-linked by four intramolecular disulfide bridges. Immunochemically, toxin FvII is completely distinct fro...