نتایج جستجو برای: dehydro aromatization

تعداد نتایج: 1931  

2008
Hongjun You

The aromatization reaction of liquefied petroleum gas has been studied by using three liquefied petroleum gases as raw material and LBO-A as catalyst, and four lump kinetics models networks have been put up on the basis of lump theory and the aromatization reaction mechanism. In the network the aromatization reaction species was firstly lumped into C 4 , propylene, low molecule hydrocarbon, liq...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1979
L E Valladares A H Payne

Aromatization of testosterone in Leydig cells purified from mature rat testes was assessed. Leydig cells incubated for 4 hr with increasing concentrations of [3H]testosterone. At saturating concentrations of testosterone, human chorionic gonadotropin (hCG) acutely stimulated aromatization. This stimulation was first observed at 1 hr, an 8-fold increase being found during a 4-hr incubation. The ...

Journal: :Cancer research 1982
W R Miller R A Hawkins A P Forrest

The significance of in vitro aromatization of [7 alpha-3H]testosterone to estradiol by human breast cancer has been investigated by correlation with (a) estrogen receptor activity and (b) clinical response to endocrine therapy. Evidence for estradiol synthesis was obtained in 66 and estrogen receptor activity in 81 of 110 tumors. Whereas most estrogen receptor-positive tumors synthesized estrad...

2000
SUSUMU OHNO

The rapid and sensitive assay of lfl,2@3H-androgen aromatization by measurement of ‘HZ0 release (Thompson, E. A., Jr., and Siiteri, P. K. (1974) J. Biol. Chem. 249,5364-5372) has been analyzed to determine its applicability to initial rate studies. It was found that aromatization is the sole reaction catalyzed by lyophilized placental microsomes that causes a loss of tritium from position 1 or ...

2006
F. Naftolin Neil J. MacLusky

Central (central nervous system and pituitary) aromatization appears to be a fundamental process for endocrine control and development. Metabolism of androgens to estrogens and the subsequent metabolism of estrogens have been proven in many species, including humans, and linked to estrogen action. Thus, aromatization appears to initiate or to be involved in activities of importance to endocrine...

2015
Lingling Fan Xiaoyan Zhi Zhiping Che Hui Xu

Stereospecific nucleophilic substitution at the C-4α position of 2α-chloro-2'(2',6')-(di)halogenopicropodophyllotoxin derivatives with carboxylic acids mediated by BF3·Et2O was described. Interestingly, this stereoselective products were completely controlled by the reaction time. That is, if the reaction time was prolonged to 24.5-31 h, the resulting compounds were all transformed into the unu...

2015
Balázs Krámos Julianna Oláh

Human aromatase is responsible for the last step of estrogen biosynthesis, for the aromatization of ring A of androstenedione (ASD) or testosterone. In this work the mechanism of aromatization was studied using gas phase and hybrid QM/MM calculations. It is shown that human aromatase can efficiently catalyze the aromatization process via a Compound I (or Compound II) mediated pathway. The natur...

Journal: :Circulation 2008
John W Eikelboom Graeme J Hankey Jim Thom Deepak L Bhatt P Gabriel Steg Gilles Montalescot S Claiborne Johnston Steven R Steinhubl Koon-Hou Mak J Donald Easton Christian Hamm Tingfei Hu Keith A A Fox Eric J Topol

BACKGROUND Incomplete inhibition of platelet thromboxane generation, as measured by elevated urinary 11-dehydro thromboxane B(2) concentrations, has been associated with an increased risk of cardiovascular events. We aimed to determine the external validity of this association in aspirin-treated patients enrolled in the Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Mana...

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