background: poly chlorinated biphenyls (pcbs) are a class of chlorinated organic chemicals that do not easily degrade in the environment. this study was conducted to determine the effect of microwave rays, hydrogen peroxide, dioxide titanium and ethanol solvent on the degradation of pcbs. methods: a 900w domestic mw oven with a fixed frequency of 2450 mhz was used to provide mw irradiation. ray...

in plants, γ-aminobutyric acid (gaba) is synthesized by polyamine degradation pathway besides gaba shunt. aminoguanidine (ag) is a specific inhibitor of the key enzyme (diamine oxidase, dao) for gaba formation in polyamine degradation pathway. in this study, ag was applied to study the functions of polyamine degradation pathway on growth and gaba accumulation in germinating fava bean under hypo...

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General nutritional strategies to promote whole body protein retention, particularly with relation to exercise, have been largely based on adult research that does not consider the dynamic process of growth and often ignores scenarios commonly experienced by children (e.g., exercise in the heat). Therefore, the aim of the present review is to highlight the importance of post-exercise protein qu...

1. Department of Human Genetics, University of Chicago. 920 E 58th St, CLSC 317. Chicago, IL, 60637, USA 2. Present address: Department of Biology, Massachusetts Institute of Technology. 31 Ames Street, 68-271A. Cambridge, MA 02139-4307, USA 3. Present address: Department of Evolutionary Anthropology and Duke Population Research Institute, Duke University. 125 Science Drive, Durham, NC 27708, USA.

We analyse a simple kinase model that exhibits bistability when there is no protein turnover, and show analytically that the property of being bistable is not necessarily conserved when degradation and synthesis of the kinase are taken into account.

In cell signaling systems, the abundances of signaling molecules are generally thought to determine the response to stimulation. However, the kinetics of molecular processes, for example receptor trafficking and protein turnover, may also play an important role. Few studies have systematically examined this relationship between the resting state and stimulus-responsiveness. Fewer still have inv...

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The Hsp70 co-chaperone CHIP has recently gained attention as a regulator of protein turnover. CHIP has now been reported to be a component of the ubiquitination cascade, specifically an E3 ligase. CHIP appears to be part of a system that diverts incorrectly folded proteins from chaperones to the proteasome.