Vestibular neuritis is defined as a sudden unilateral partial failure of the vestibular nerve that impairs the forwarding of vestibular information from the labyrinth. The patient suffers from vertigo, horizontal nystagmus and postural instability with a tendency toward ipsilesional falls. Although vestibular neuritis is a common disease, the central mechanisms to compensate for the loss of pre...

Youth with perinatally acquired human immunodeficiency virus (PHIV+) survive longer with combination antiretroviral therapy, but remain at risk for poor cognitive outcomes. We evaluated whether markers of HIV disease severity relate to default mode resting-state functional connectivity in PHIV+ youth. We conducted resting-state functional neuroimaging and cognitive testing in a subset of 40 PHI...

Introduction: The dynamics of resting state networks during active and passive task performance has received increased attention in recent times [1, 2]. Several studies have reported modulations in the default mode network (DMN) (or deactivations) during the performance of sensoryand cognitivefMRI tasks [1, 2, 3]. However, no study has investigated such modulations in relation to olfaction. Usi...

Reflecting one's mental self is a fundamental process for evaluating the personal relevance of life events and for moral decision making and future envisioning. Although the corresponding network has been receiving growing attention, the driving neurochemical mechanisms of the default mode network (DMN) remain unknown. Here we combined positron emission tomography and functional magnetic resona...

Major depressive disorder (MDD) is associated with alterations in multiple brain networks including the default mode network (DMN). The DMN is a set of large-scale connected brain regions that oscillate synchronously and are more active during rest relative to goal-directed tasks. Several functions have been hypothesized for the DMN, including cognitive, self-referential and social functions. W...

The default mode network (DMN) is a complex dynamic network that is critical for understanding cognitive function. However, whether dynamic topological reconfiguration of the DMN occurs across different brain states, and whether this potential reorganization is associated with prior learning or experience is unclear. To better understand the temporally changing topology of the DMN, we investiga...

Insufficient suppression and connectivity of the default mode network (DMN) is a potential mediator of cognitive dysfunctions across various disorders, including attention deficit/hyperactivity disorder (ADHD). However, it remains unclear if alterations in sustained DMN suppression, variability and connectivity during prolonged cognitive engagement are implicated in adult ADHD pathophysiology, ...

A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network (DMN), its function has been associated with memory processing, and it has been referred to as the parietal memory network (PMN). Independent component analysis (IC...

The Default Mode Network (DMN) regions exhibit deactivation during a wide variety of resource demanding tasks. However, recent brain imaging studies reported that they also show activation during various cognitive activities. In addition, studies have found a negative correlation between the DMN and the working memory network (WMN). Here, we investigated activity in the DMN and WMN regions duri...

Recent neuroimaging studies have led to the proposal that a specific set of regions, referred to as the default mode network (DMN), is engaged when individuals are at rest. Temporal activity within the network is characterized by spontaneous intrinsic low-frequency fluctuations. However, it is still unclear how the low-frequency temporal connectivity within DMN regions changes under different t...