Deet is considered to be the best "all around" insect repellent ever developed and is the most widely used insect repellent in the world. Since its first use in a consumer product in 1956, billions of applications have been made to human skin. Information about the safety of deet comes from the human clinical literature, animal toxicology studies, and poison control centers' experiences with de...

N,N-Diethyl meta Toluamide (DEET) is an insect repellent agent that contrary to its benefits,if is used in formulations with high skin permeation, will produce side effects of differentseverity. This study attempted to achieve a semi-solid DEET containing formulation withgood appearance, sufficient spreadity, suitable viscosity for tube and jar filling, compatible pHwith skin, reasonable stabil...

In a Central Michigan wetland setting, air drawn through a DEET-impregnated screen using an electric fan and projected toward a human subject significantly reduced mosquito orientation by 74%, landing by 75%, and probing by 70%, relative to no applied wind or DEET. The DEET vapor effect was significant as revealed by a statistically significant wind/DEET interaction. The wind speed at the downw...

DEET (N,N-diethyl-meta-toluamide) is the world's most widely used topical insect repellent, with broad effectiveness against most insects. Its mechanism of action and molecular target remain unknown. Here, we show that DEET blocks electrophysiological responses of olfactory sensory neurons to attractive odors in Anopheles gambiae and Drosophila melanogaster. DEET inhibits behavioral attraction ...

The insect repellent N,N-diethyl-m-toluamide (DEET) has been reported to inhibit AChE (acetylcholinesterase) and to possess potential carcinogenic properties with excessive vascularization. In the present paper, we demonstrate that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis in...

Oxidative metabolism of the insect repellent N,N-diethyl-m-toluamide (DEET) by pooled human liver microsomes (HLM), rat liver microsomes (RLM), and mouse liver microsomes (MLM) was investigated. DEET is metabolized by cytochromes P450 (P450s) leading to the production of a ring methyl oxidation product, N,N-diethyl-m-hydroxymethylbenzamide (BALC), and an N-deethylated product, N-ethyl-m-toluami...

N, N-diethyl-m-toluamide (DEET) is one of the important emerging contaminants that are being increasingly detected in reclaimed water as well as in drinking water sources. However, DEET is refractory to conventional biological treatment and pure ozone which is absent of hydroxyl radical. Current researches on the efficient removal of DEET are still quite limited. This study utilizes a novel met...

This study determined the effects of contact with DEET on guinea pig skin on mortality, probing time, blood feeding rate, engorgement time, and fecundity responses in female Anopheles quadrimaculatus Say. Exposure, in this manner, to 10% DEET (in ethanol) for 5 min, resulted in 98% mortality in mosquitoes after 24h. The median probing time (PT(50)) required by females, when exposed to 0.1%, 1.0...

N,N-Diethyl-m-toluamide (DEET) is one of the most effective and commonly used mosquito repellents. However, during laboratory trials a small proportion of mosquitoes are still attracted by human odors despite the presence of DEET. In this study behavioral assays identified Aedes aegypti females that were insensitive to DEET, and the selection of either sensitive or insensitive groups of females...

J. Med. Entomol. 37(6): 919-923 (2000) ABSTRACT Repellent efficacy of N,N-diethyl-3-methyl-benzamide (deet), the piperidine, 1-[3cyclohexen-1-ylcarbonyl] -2-methylpiperidine (AI3-37220), and a 1:l ratio of deet + AI3-37220 were evaluated topically (0.25 mglcm’ applied in ethanol solution) on human volunteers against the mosquito Aed+z.s communis (DeGeer) and the black fly Simulium. venusturn Sa...