INTRODUCTION: DDT is an organochlorine insecticide used mainly to control mosquito-borne malaria; use on crops has generally been replaced by less persistent insecticides (79). It was extensively used during the Second World War among Allied troops and certain civilian populations to control insect typhus and malaria vectors, and was then extensively used as an agricultural insecticide after 19...

Mallard ducks were fed diets containing various levels of technical DDT or chemically pure p,p'-DDT, or dieldrin. Either technical DDT or p,p'-DDT at 20 ppm or greater, or dieldrin at I 0 ppm caused a statistically significant reduction in e9gshell thickness, weight, and calcium. Shells of eggs from ducks fed 40 ppm of p,p -DDT were about 20% thinner than those from control ducks, and shells of...

Dichlorodiphenyltrichloroethane (DDT) metabolism-based resistance in Drosophila melanogaster is a complex metabolic system associated with the transcription of detoxification related genes, ion transport, lipid and sugar metabolism pathways. However, little is known about the differences regarding the proteome of field- and laboratory-selected resistant Drosophila genotypes. We investigated the...

BACKGROUND Indoor residual spraying (IRS) of DDT is used to control visceral leishmaniasis (VL) in India. However, the quality of spraying is severely compromised by a lack of affordable field assays to monitor target doses of insecticide. Our aim was to develop a simple DDT insecticide quantification kit (IQK) for monitoring DDT levels in an operational setting. METHODOLOGY/ PRINCIPLE FINDIN...

The transfer of p,p'-DDT (1,1,1-tricholoro-2,2-bis(4-chlorophenyl)ethane) and its metabolites to infants via breast-feeding was studied in an area of KwaZulu, South Africa, where DDT is used to interrupt malaria transmission. Samples of whole blood were collected from 23 infants, together with samples of breast milk from their respective mothers. The mean sigma DDT (total DDT) in the whole bloo...

BACKGROUND Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, body lice, and bubonic plague worldwide, until countries began restricting its use in the 1970s. However, the use of DDT to control vector-borne diseases continues in developing countries. Prenatal DDT exposure is associated with elevated blood pressure in humans. OBJECTIVE We hypothesized that p...

Background: The organochlorine DDT has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. In the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-DDT [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-DDE (2-2-bis(4/chlorophenyl)-1-1-di...

The Stockholm Convention on Persistent Organic Pollutants granted a controversial exemption for some countries to continue using DDT. DDT has a history of use in malaria control, but widespread concern about health risks led to declining use. A science-based policy analysis of existing published literature was conducted to consider DDT toxicology and malaria risk in South Africa to generate dat...

Indoor residual spraying with DDT was the principle method by which malaria transmission was eradicated or greatly reduced in many countries between the late 1940s and 1970s. Since then, decreasing use of DDT has been associated with a resurgence of malaria in India, Sri Lanka, former Soviet Central Asia, Zanzibar, Venezuela and several other Latin American countries. In India and Zanzibar, DDT...