In recent years, graphene and its derivatives have attracted much interest in various fields, including biomedical applications. In particular, increasing attention has been paid to the effects of reduced graphene oxide (rGO) on cellular behaviors. On the other hand, dicalcium phosphate (DCP) has been widely used in dental and pharmaceutical fields. In this study, DCP composites coated with rGO...

The aim of this study was to evaluate the chemical stability of diphenylcyclopropenone (DCP) in var- ious solvents. DCP is being used in topical therapy in patients with alopecia areata (AA). The solvents for DCP used so far were acetone, ethanol and propylene glycol. DCP is supposed to be an immune-modulating thera- peutic agent, however the studies on it's pharmacokinetics including chemical ...

Because of the concerns that exposure to 2,4-dicholorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) may adversely affect pregnancy outcomes, this study was undertaken to evaluate the impact of pregnancy on the levels of 2,4-DCP and 2,5DCP. Data from National Health and Nutrition Examination Survey were used to fit regression models to evaluate this association with adjustment for other fact...

Recently, epidemiological studies revealed a positive relationship between an outbreak of occupational cholangiocarcinoma and exposure to organic solvents containing 1,2-dichloropropane (1,2-DCP). In 1,2-DCP-administered animal models, we previously found biliary excretion of potentially oncogenic metabolites consisting of glutathione- (GSH-) conjugated forms of 1,2-DCP (GS-DCPs); however, the ...

The yield coefficient (YC) of Pseudomonas sp. strain DP-4, a 2, 4-dichlorophenol (DCP)-degrading organism, was estimated from the number of CFU produced at the expense of 1 unit amount of DCP at low concentrations. At a low concentration of DCP, the YC can be overestimated in pure culture, because DP-4 assimilated not only DCP but also uncharacterized organic compounds contaminating a mineral s...

BACKGROUND/AIMS The linoleic acid derivative DCP-LA selectively and directly activates PKCε. The present study aimed at understanding the mechanism of DCP-LA-induced PKCε activation. METHODS Point mutation in the C2-like domain on PKCε was carried out, and each kinase activity was monitored in PC-12 cells using a föerster resonance energy transfer (FRET) probe with cyan fluorescent protein (C...

Based on the findings of epidemiological studies in Japan that occupational exposure to 1,2-dichloropropane (1,2-DCP) was associated with increased cholangiocarcinomas, 1,2-DCP has recently been classified as being carcinogenic to humans (Group 1). However, the cholangiocarcinogenicity of 1,2-DCP has not been demonstrated experimentally, and it was negative for cholangiocarcinogenicity in rats ...

OBJECTIVES The aim of this study was to examine the applicability of urinalysis for unmetabolized solvent to biomonitor 1,2-dichloropropane (1,2-DCP) exposure. METHODS Thirty three male printers exposed to 1,2-DCP and 5 nonexposed male controls participated in the study. The 8-hr average levels of exposure to 1,2-DCP in air and 1,2-DCP in the end-of-shift urine samples were measured with capi...

1H NMR measurements of spin-lattice (T1) and spin-spin (T2) relaxation times and diffusion ordered spectroscopy (DOSY) were applied to investigate the association of 2,4-dichlorophenol (DCP) with a soil fulvic (FA-VICO) and humic acid (HA(-)-VICO), and a lignite humic acid (HA-LIG). The 1H T1 and T2 values of DCP were found to decrease with increasing humic concentration, indicating reduction i...

in order to determine the effects of substitution of barley grain with dried citrus pulp (dcp) on eight lactating holstein cows with average body weight of 550 ± 50 kg and 75 ± 15 days in milk were allocated to 4 dietary treatments, which were diet; the control with 0% dried citrus pulp (dcp) and 15% barley grain, diet 2, 3 and 4 containing 5, 10 and 15% dcp and 10, 5 and 0% barley grain respec...