Because of the concerns that exposure to 2,4-dicholorophenol (2,4-DCP) and 2,5-dichlorophenol (2,5-DCP) may adversely affect pregnancy outcomes, this study was undertaken to evaluate the impact of pregnancy on the levels of 2,4-DCP and 2,5DCP. Data from National Health and Nutrition Examination Survey were used to fit regression models to evaluate this association with adjustment for other fact...

Recently, epidemiological studies revealed a positive relationship between an outbreak of occupational cholangiocarcinoma and exposure to organic solvents containing 1,2-dichloropropane (1,2-DCP). In 1,2-DCP-administered animal models, we previously found biliary excretion of potentially oncogenic metabolites consisting of glutathione- (GSH-) conjugated forms of 1,2-DCP (GS-DCPs); however, the ...

The yield coefficient (YC) of Pseudomonas sp. strain DP-4, a 2, 4-dichlorophenol (DCP)-degrading organism, was estimated from the number of CFU produced at the expense of 1 unit amount of DCP at low concentrations. At a low concentration of DCP, the YC can be overestimated in pure culture, because DP-4 assimilated not only DCP but also uncharacterized organic compounds contaminating a mineral s...

BACKGROUND/AIMS The linoleic acid derivative DCP-LA selectively and directly activates PKCε. The present study aimed at understanding the mechanism of DCP-LA-induced PKCε activation. METHODS Point mutation in the C2-like domain on PKCε was carried out, and each kinase activity was monitored in PC-12 cells using a föerster resonance energy transfer (FRET) probe with cyan fluorescent protein (C...

Based on the findings of epidemiological studies in Japan that occupational exposure to 1,2-dichloropropane (1,2-DCP) was associated with increased cholangiocarcinomas, 1,2-DCP has recently been classified as being carcinogenic to humans (Group 1). However, the cholangiocarcinogenicity of 1,2-DCP has not been demonstrated experimentally, and it was negative for cholangiocarcinogenicity in rats ...

OBJECTIVES The aim of this study was to examine the applicability of urinalysis for unmetabolized solvent to biomonitor 1,2-dichloropropane (1,2-DCP) exposure. METHODS Thirty three male printers exposed to 1,2-DCP and 5 nonexposed male controls participated in the study. The 8-hr average levels of exposure to 1,2-DCP in air and 1,2-DCP in the end-of-shift urine samples were measured with capi...

1H NMR measurements of spin-lattice (T1) and spin-spin (T2) relaxation times and diffusion ordered spectroscopy (DOSY) were applied to investigate the association of 2,4-dichlorophenol (DCP) with a soil fulvic (FA-VICO) and humic acid (HA(-)-VICO), and a lignite humic acid (HA-LIG). The 1H T1 and T2 values of DCP were found to decrease with increasing humic concentration, indicating reduction i...

in order to determine the effects of substitution of barley grain with dried citrus pulp (dcp) on eight lactating holstein cows with average body weight of 550 ± 50 kg and 75 ± 15 days in milk were allocated to 4 dietary treatments, which were diet; the control with 0% dried citrus pulp (dcp) and 15% barley grain, diet 2, 3 and 4 containing 5, 10 and 15% dcp and 10, 5 and 0% barley grain respec...

An airlift inner-loop bioreactor packed with honeycomb-like ceramic as the carrier was developed and its capacity to immobilize microorganism was studied through adding bacteria, Achromobacter sp., capable of degrading 2,4-dichlorophenol (2,4-DCP), directly to the reactor under continuous operation. Effects of phenol in the feed with 2,4-DCP on 2,4-DCP removal were investigated under fed-batch ...

This study compared the metabolic fate of [(14)C]-DCP, [(14)C]-residues from radish plants, and purified [(14)C]-DCP-(acetyl)glucose following oral administration in rats. A rapid excretion of radioactivity in urine occurred for [(14)C]-DCP, [(14)C]-DCP-(acetyl)glucose, and soluble residues, 69, 85, and 69% within 48 h, respectively. Radio-HPLC profiles of 0-24 h urine from rats fed [(14)C]-DCP...