Knowledge of how neutrophils respond to chemotactic signals in a complex inflammatory environment is not completely understood. Moreover, even less is known about factors in physiological fluids that regulate the activity of chemoattractants. The vitamin D-binding protein (DBP) has been shown to significantly enhance chemotaxis to complement activation peptide C5a using purified proteins in vit...

Nowadays business is rapidly changing to fulfil the customers’ needs and to meet the requirements of a changing environment. All those changes of a business have to be implemented in business processes (BP) and their maintaining information systems. Therefore, a necessity for a new approach of dynamic business process (DBP) modelling arises. Moreover, business needs a tool suitable for DBP mode...

BACKGROUND Serum 25-hydroxyvitamin D (25OHD) is a key factor in determining monocyte induction of the antimicrobial protein cathelicidin, which requires intracrine conversion of 25OHD to 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. Both vitamin D metabolites circulate bound to vitamin D-binding protein (DBP), but the effect of this on induction of monocyte cathelicidin remains unclear. METHODS Hum...

Di butyl phthalate (DBP) is an environmental contaminant used in the production of plastics, cosmetics and medical devices. Pregnant women may be exposed to DBP through diet and daily consumer products. In present study, the effects of DBP on reproductive function of pregnant mice were investigated. Pregnant females were given DBP through gastric intubation at 0, 250 and 1000 mg / kg body weigh...

DBP, a PAR leucine zipper transcription factor, accumulates according to a robust circadian rhythm in liver and several other tissues of mouse and rat. Here we report that DBP mRNA levels also oscillate strongly in the suprachiasmatic nucleus (SCN) of the hypothalamus, believed to harbor the central mammalian pacemaker. However, peak and minimum levels of DBP mRNA are reached about 4 h earlier ...

Actin is the most abundant protein in eukaryotic cells, but its release from cells into blood vessels can be lethal, being associated with clinical situations including hepatic necrosis and septic shock. A homeostatic mechanism, termed the actin-scavenger system, is responsible for the depolymerization and removal of actin from the circulation. During the first phase of this mechanism, gelsolin...

BACKGROUND To repair fractures with large bone defects or gaps, demineralized allogenic bone matrix (DBM) is often applied to the fracture site. However, studies have shown that the use of DBM alone has limited efficacy for repairing fractures. In the present study, we developed an allogenic demineralized bone powder (DBP) with basic fibroblast-derived growth factor containing a polycystic kidn...

this study was conducted in two separate experiments. four rumen-cannulated sheep were allocated in the first experiment to evaluate date by-product (dbp) and date seed (ds) nutrients degradation in rumen. in experiment two eighteen fattening lambs were allocated in three different treatments (6 animals/treatment) to evaluate dbp effects on animal performance and nutrients’ digestibility. three...

The dependence of Plasmodium vivax on invasion mediated by Duffy binding protein (DBP) makes this protein a prime candidate for development of a vaccine. However, the development of a DBP-based vaccine might be hampered by the high variability of the protein ligand (DBP(II)), known to bias the immune response toward a specific DBP variant. Here, the hypothesis being investigated is that the ana...

Vitamin D binding protein (DBP) is a multifunctional plasma transport protein that is also found on the surface of many cell types. Cell surface DBP significantly enhances chemotactic activity of complement (C) peptides C5a and C5a des Arg. However, both DBP binding and C5a chemotaxis enhancement can vary among neutrophil donors. To test if activation during cell purification is responsible for...