نتایج جستجو برای: daz gene

تعداد نتایج: 1141522  

Journal: :medical journal of islamic republic of iran 0
h najmabadi from the welfare science and rehabilitation university (hn), tehran, iran; karimi-nejad pathology & genetic center (hn, ss, fs), tehran, iran; division of endocrinology, metabolism, and molecularmedicine (kk. wt, lr, an, mg, sb) and department of obstetrics and gynecology (bs), charles r.drew university of medicine and science, los angeles, ca, usa; department of obstetrics andgynecology, university of melbourne, australia; institute of reproduction and development (dmdk,rim. kal), monash university, melbourne, australia, and prince henry:s medical research institute (rimc), and karolinska institute, stokholm, sweden (s a). dm de kretser s arver w taylor c mallidis hw gorden baker

it is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (azf) in yq 11.23. however, it is not known whether yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (oligo...

Journal: :Human reproduction 1997
J P Mulhall R Reijo R Alagappan L Brown D Page R Carson R D Oates

Some men with non-obstructive azoospermia harbour fully formed spermatozoa within their testicular tissue that can be used to achieve pregnancy via intracytoplasmic sperm injection (ICSI). Recently, Reijo et al. (1995) provided compelling evidence that the DAZ gene cluster is a strong candidate for one of the elusive azoospermia factors (AZF) located on the long arm of the Y chromosome. The DAZ...

Journal: :Biology of reproduction 2000
R A Reijo D M Dorfman R Slee A A Renshaw K R Loughlin H Cooke D C Page

The human DAZ gene family is expressed in germ cells and consists of a cluster of nearly identical DAZ (deleted in azoospermia) genes on the Y chromosome and an autosomal homolog, DAZL (DAZ-like). Only the autosomal gene is found in mice. Y-chromosome deletions that encompass the DAZ genes are a common cause of spermatogenic failure in men, and autosomal homologs of DAZ are essential for testic...

Journal: :Molecular biology and evolution 2001
J P Bielawski Z Yang

Because a microdeletion containing the DAZ gene is the most frequently observed deletion in infertile men, the DAZ gene was considered a strong candidate for the azoospermia factor. A recent evolutionary analysis, however, suggested that DAZ was free from functional constraints and consequently played little or no role in human spermatogenesis. The major evidence for this surprising conclusion ...

Journal: :Molecular human reproduction 2006
Ana Teresa Fernandes Susana Fernandes Rita Gonçalves Rosália Sá Paula Costa Alexandra Rosa Cristina Ferrás Mário Sousa António Brehm Alberto Barros

The DAZ gene, a contributing factor in infertility, lies on the human Y chromosome's AZFc region, whose deletion is a common cause of spermatogenic failure. Y chromosome binary polymorphisms on the non-recombining Y (NRY) region, believed to be a single occurrence on an evolutionary scale, were typed in a sample of fertile and infertile men with known DAZ backgrounds. The Y single-nucleotide po...

Journal: :Molecular human reproduction 1997
N N Chai A Phillips A Fernandez P H Yen

The DAZLA (DAZ Like Autosomal) gene on human chromosome 3 shares a high degree of homology with the DAZ (Deleted in AZoospermia) gene family on the Y chromosome, a gene family frequently deleted in males with azoospermia or severe oligospermia. The involvement of both DAZ and DAZLA in spermatogenesis is suggested by their testis-specific expression and their homology with a Drosophila male infe...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Harini Iyer Melanie Issigonis Prashant P Sharma Cassandra G Extavour Phillip A Newmark

Mutations in Deleted in Azoospermia (DAZ), a Y chromosome gene, are an important cause of human male infertility. DAZ is found exclusively in primates, limiting functional studies of this gene to its homologs: boule, required for meiotic progression of germ cells in invertebrate model systems, and Daz-like (Dazl), required for early germ cell maintenance in vertebrates. Dazl is believed to have...

2009
Hongyan Xu Zhendong Li Mingyou Li Li Wang Yunhan Hong

BACKGROUND The DAZ family genes boule, daz and dazl encode RNA binding proteins essential for fertility of diverse animals including human. dazl has bisexual expression in both mitotic and meiotic germ cells, whereas daz has male premeiotic expression, and boule is largely a unisexual meiotic regulator. Although boule has been proposed as the ancestor for dazl/daz by gene duplication, it has be...

Journal: :Biology of reproduction 2000
S Tsui T Dai S T Warren E C Salido P H Yen

The DAZ (Deleted in AZoospermia) gene family was isolated from a region of the human Y chromosome long arm that is deleted in about 10% of infertile men with idiopathic azoospermia. DAZ and an autosomal DAZ-like gene, DAZL1, are expressed in germ cells only. They encode proteins with an RNA recognition motif and with either a single copy (in DAZL1) or multiple copies (in DAZ) of a DAZ repeat. A...

Journal: :Human molecular genetics 1996
Z Shan P Hirschmann T Seebacher A Edelmann A Jauch J Morell P Urbitsch P H Vogt

We have isolated a series of human testis poly(A) cDNA clones by cross-hybridization to SPGY1, a Y gene homologous to DAZ. Their sequence analysis revealed an identical nucleotide composition in different 'full-length' clones, suggesting that all were encoded by the same gene. We mapped this gene to the short arm of chromosome 3 and designated it SPGYLA (SPGY like autosomal). Comparison of the ...

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