Centriole duplication occurs once per cell cycle, ensuring that each cell contains two centrosomes, each containing a mother-daughter pair of tightly engaged centrioles at mitotic entry. Loss of the tight engagement between mother and daughter centrioles appears to license the next round of centriole duplication. However, the molecular mechanisms regulating this process remain largely unknown. ...

Context The maternal heritability of bone microarchitecture according to the sex of the offspring is not known. Objective To explore sex difference and influence of mother's menopausal status on the heritability of bone microarchitecture between mothers and their offspring. Subjects and Methods In 102 mother-daughter and 161 mother-son pairs, volumetric bone mineral density (BMD) and bone m...

Objective. A multi-phase, sequential mixed methods study aimed to determine acceptable age-appropriate physical intimate behaviors shared between Filipino parents and children that are related hygiene, affection privacy.
 Methods. Following an exploratory qualitative phase (Phase 1) instrumentation 2), the quantitative survey 3) utilized resultant Family Behavior Questionnaire (FFBQ). tota...

BACKGROUND Parental obesity is a known determinant of childhood obesity. Previous research has shown a strong maternal influence on body mass index (BMI) during infancy and early childhood. OBJECTIVES The purpose of this research was to investigate the BMI associations between mother and offspring from birth to age 18 years. METHODS Participants were selected from the Fels Longitudinal Stud...

Using a new technique to visualize the tracks of moving 3T3 cells and combining it with the visualization of actin-containing microfilament bundles by indirect immunofluorescence (Lazarides, E. and K. Weber. 1974, Proc. Natl. Acad. Sci. U.S.A. 71:2268-2272), I present experiments which suggest that: (a) 30-40% of the pairs of daughter 3T3 mouse fibroblasts in noncloned cultures have mirror sym...

Susceptibility to primary biliary cirrhosis (PBC) may be partly inherited although instances of PBC within families are only infrequently described. The records of 736 patients with PBC seen over a 25 year period were examined to identify those with a positive family history. Ten patients originating from eight families were identified, giving a frequency of 1.33%. They comprised mother and dau...

It is known that chromosomes occupy non-random positions in the cell nucleus. However, it is not clear to what extent their nuclear positions, together with their neighborhood, are conserved in daughter cells. To address specific aspects of this problem, we used the model of the chromosomes carrying ribosomal genes that are organized in clusters termed Nucleolus Organizer Regions (NORs). We com...

Mother-daughter relationships are generally characterized by frequent contact and high levels of regard. Yet little is known about what mothers and daughters find enjoyable about their contact. Forty-eight pairs of older mothers (M = 76 years) and their middle-aged daughters (M = 46 years) and 44 pairs of middle-aged mothers (M = 47 years) and their young adult daughters (M = 21 years) (N = 182...

We analyzed the differentiation of hemopoietic colonies derived from human paired daughter cells. Candidate progenitor cells were isolated by use of a micromanipulation technique from cultures of My-10 antigen-positive cord blood cells. Then nine to 36 hours later, the paired daughter cells were separated with a micromanipulator and allowed to form colonies in methylcellulose medium containing ...

There are many small bits of conventional wisdom in biology whose general truths may be widely assumed, despite limited evidence from rather narrow circumstances. One such bit of wisdom concerns the random separation of chromosomes into daughter cells during mitosis. In a new study, Thomas Rando and colleagues show that for muscle stem cells, that separation is anything but random. Before every...