Calmodulin inhibitors enhance cytotoxic effects of doxorubicin (DOX) in DOX-resistant (P388/DOX) P388 mouse leukemia cells by increasing cellular accumulation and retention of drug. In P388/DOX cells treated for 3 hr, cytotoxic effects (based on colony formation in soft agar) of daunorubicin (DAU) in the presence of trifluoperazine (TFP) were DAU concentration-dependent and enhanced 2- to 100-f...

Neutral pion (π 0) production is calculated in a leading order (LO) perturbative QCD-based model in pp and dAu collisions at √ s = 200 AGeV at midrapidity. The model includes the transverse component of the initial parton distribution. We compare our results for pp collision to experimental data at RHIC energy. We repeat our calculation for the dAu collision and investigate the interplay betwee...

N-Allyl derivatives of uracil (U), thymine (T) and 6-methyluracil (6-MU) were prepared, and their pharmacological activities (hypnotic activity and anticonvulsant activity against pentylenetetrazol (PTZ)-induced seizures) and interactions with three sedative-hypnotics [pentobarbital (PB), barbital (B) and diazepam (DZ)] were investigated in mice. AO,N3-Diallyluracil (DAU) alone exhibited hypnot...

The integration of business applications into workflow management systems (WfMSs) is a recent topic in workflow management. Today, most efforts are concerned mainly with the integration itself. However, considering the information need of knowledge intensive applications, new possibilities arise when using information available in workflows. With the example of document analysis and understandi...

Naringin (Nar) is a flavonoid that has shown antigenotoxic effect against the chromosome damage induced by various compounds. The aims of the present investigation on Nar were threefold: a) to determine its DNA breaking potential in mouse hepatocytes and cardiocytes, b) to evaluate its capacity to inhibit the DNA damage induced by daunorubicin (Dau) in the same tissues, and c) to determine its ...

Calculations of the nuclear modification factor, R dAu , for π 0 production in dAu collisions at √ s N N = 200 GeV are presented. The applied pQCD-improved parton model incorporates intrinsic k T. Nuclear multiscattering and nuclear shadowing are considered in the Au nucleus. Theoretical results are displayed for midrapidity and high pseudorapidity, η, and compared to preliminary PHENIX and BRA...

Calculations of the nuclear modification factor, R dAu , for π 0 production in dAu collisions at √ s = 200 AGeV are presented. The applied pQCD-improved parton model incorporates intrinsic k T. Nuclear multiscattering and nuclear shadowing are considered in the Au nucleus. Theoretical results are displayed for midrapidity and high pseudo-rapidity (η), and compared to preliminary PHENIX and BRAH...

Iron chelation is the only pharmacological intervention against anthracycline cardiotoxicity whose effectiveness has been well documented both experimentally and clinically. In this study, we aimed to assess whether pyridoxal 2-chlorobenzoyl hydrazone (o-108, a strong iron chelator) can provide effective protection against daunorubicin (DAU)-induced chronic cardiotoxicity in rabbits. First, usi...

Calculations of the nuclear modification factor, R dAu , for π 0 production in dAu collisions at √ s = 200 AGeV are presented. The applied pQCD-improved parton model incorporates intrinsic k T. Nuclear multiscattering and nuclear shadowing are considered in the Au nucleus. Theoretical results are displayed for midrapidity and high pseudorapidity (η), and compared to preliminary PHENIX and BRAHM...

Document Analysis and Understanding Bertin Klein GMD IPSI Dolivostr. 15 D 64293 Darmstadt, Germany [email protected] Andreas Abecker DFKI Postfach 2080 D 67608 Kaiserslautern, Germany [email protected] Abstract Document Analysis and Understanding (DAU) is a complex AI application with high industrial impact. For the increasing demands upon the bandwidth and quality of the analysis it is...