Background and Objectives: Studies have documented the morhplogical, neurochemical and functional difference between the dorsal and ventral zones of hippocampus. The aim of this study was to assess the effects of chronic diabetes mellitus type1 on ventral and dorsal zones of hippocampus. Methods: Experimental diabetes was induced by stereptozotocin at a dose of 60 mg/kg. At the end of 8 wee...

spreading depression (sd), discovered by leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes. sd appears to act through several mechanisms and receptors which have not completely understood. here, we studied the effect of inhibitory system in animal model of sd using immunohistochemistry technique. after imp...

The aimof research was to study morphofunctional signs of the sensorimotor "dark neurons" formation in cerebrum sexually mature white rats under normal conditions and 40 minutesafter common carotid arteries (CCA) occlusion. Material methods.Acute ischemia simulated Wistar by a 40-min CCA brain fixed immersion perfusion methods. A comparative morphometric assessment cyto-and gliocytoarchitectoni...

traumatic brain injury resulting road accidents create damage to the brain. the severe brain injury may cause extensive tissue loss of several parenchyma which results in cavities due to primary destruction and secondary injuries such as ischemia and inflammation. recent findings suggest that neuronal precursors in the adult mammalian brain can be a therapeutic target in ischemic brain injuries...

Subpopulations of adult frog dorsal root ganglion (DRG) neurons respond to different physiological stimuli, and have unique biophysical and pharmacological properties. Two broad-based subpopulations of DRG neurons appear under phase optics, "large clear" and "small dark" neurons, while immunochemical and electrophysiological techniques allow identification of additional subpopulations. Neverthe...

The response properties and receptive field organization of 106 LSA neurons were investigated in pretrigeminal preparations using moving dark and bright stimuli with particular reference to the dynamic and static structure of receptive fields. About 61percent neurons revealed equal sensitivity to the motions of dark and bright stimuli. A majority of them had an ON-OFF static structure of recept...

This study aims to investigate the occurrence and nature of dark neurons in the central nervous system under physiological conditions. Mouse brain tissues were perfusion-fixed with paraformaldehyde or glutaraldehyde at 4 h intervals during one day (3:00, 7:00, 11:00, 15:00, 19:00, 23:00). Paraffin sections were stained with the cationic colloidal iron method, and counterstained with nuclear fas...

early life stress during fetal development has been hypothesized to predispose several neurological and psychiatric disorders in adulthood. the purpose of this study was to investigate the effect of maternal stress on the volume of granular cells, total number of dark neurons and also the distribution of glycol-conjugates and changes of terminal sugars in the dentate gyrus. pregnant sprague-daw...