The D2 dopamine receptor (D2 DAR) is one of the most validated drug targets for neuropsychiatric and endocrine disorders. However, clinically approved drugs targeting D2 DAR display poor selectivity between the D2 and other receptors, especially the D3 DAR. This lack of selectivity may lead to undesirable side effects. Here we describe the chemical and pharmacological characterization of a nove...

Dialect speakers in the North of England use vowel-less forms of the definite article (the) which are unattested in English varieties elsewhere and have been termed Definite Article Reduction (DAR). Previous research on DAR has provided detailed phonological descriptions, but less insight has been gained into other aspects of DAR like its emergence and the northern pattern of occurrence. I demo...

Studies involving lambda phage transduction of the D-arabinose utilization gene (dar+) in Escherichia coli K-12 indicated the product of this gene to be a transdominant activator. An apparent anomaly regarding this hypothesis exists in that a diploid recessive lysogen (lambda dar-/dar-) can spontaneously become capable of growth on D-arabinose.

In a recent paper Dar and Shaviv (1994) presented results of calculations with an improved standard solar model (SSM) that suggest a standard physics solution to the solar neutrino problem. In a subsequent publication with a similar title Bahcall et al. (1994) have claimed to refute the results obtained by Dar and Shaviv. Here we show that the criticism and conclusions of Bahcall et al. are unj...

INTRODUCTION The aim of this study was to examine provider perceptions concerning the provision and accessibility of diabetes education, according to levels of economic distress and rurality throughout the US Appalachian region. METHODS A questionnaire regarding diabetes education resources was developed and mailed to all Federally Qualified Health Centers (FQHC), health departments, and know...

The highly polymorphic Rh system is encoded by 2 homologous genes RHD and RHCE. Gene rearrangements, deletions, or point mutations may cause partial D and CE antigens. In this study, a new RHD variant, DAR, and a new RHCE variant, ceAR, are described in 4 Dutch African Blacks. Serologically, DAR showed weaker reactions with a monoclonal antibody and polyclonal antiserum against D. The DAR pheno...

P.O. Box 447, Arusha, Tanzania. 2 Ifakara Health Institute, P.O. Box 78373, Dar es Salaam, Tanzania. 3 Dar es Salaam Institute of Technology, P. O. Box 2958, Dar es Salaam, Tanzania. 4 National Institute for Medical Research, Amani Medical Research Centre, P.O. Box 81, Muheza, Tanga, Tanzania. 5 Genome Science Centre and Department of Veterinary Microbiology and Parasitology, Sokoine University...

BACKGROUND Cleft lip and palate (CLP) is one of the most common birth defects. Multiple factors are believed to be responsible for an unfavorable dental arch relationship in CLP. Facial growth (maxillary) retardation, which results in class III malocclusion, is the primary challenge that CLP patients face. Phenotype factors and postnatal treatment factors influence treatment outcomes in unilate...

BACKGROUND Development of a tuberculosis vaccine to boost BCG is a major international health priority. SRL172, an inactivated whole cell booster derived from a non-tuberculous mycobacterium, is the only new vaccine against tuberculosis to have demonstrated efficacy in a Phase 3 trial. In the present study we sought to determine if a three-dose series of DAR-901 manufactured from the SRL172 mas...