Transcriptional repression is a key mechanism for the spatial specification of gene expression and cell fate determination. During kidney development, proliferating cell nuclear antigen (PCNA) is expressed in the nephrogenic zone and is downregulated rapidly as renal epithelial cells enter terminal differentiation and acquire functional characteristics. Our laboratory reported that the transcri...

Glyeophorin A (GpA), which is the major sialoglyeoprotein on human red eells, is one of the best eharaeterized mammalian integral membrane proteins (Marehesi et al. 1972; Tomita and Marehesi 1975). Its amino acid sequenee is known. The protein moleeule eontains three distinet domains. A large hydrophilie portion, earrying the NHrterminal, is loeated on the external surfaee of the red eell, and ...

Aberrant gene-environment interactions are implicated in the pathogenesis of congenital renal dysgenesis (CRD), a leading cause of renal failure in infants and children. We have recently developed an animal model of CRD that is caused by gestational salt stress (5% NaCl diet; HS) of bradykinin B2R null mice [B2R(-/-)CRD; El-Dahr SS, Harrison-Bernard LM, Dipp S, Yosipiv IV, and Meleg-Smith S. Ph...

THE effects of an accumulation of carbon dioxide and of a lack of oxygen on the respiratory movements of mammals have been intensively studied (Winterstein, 1923; Gesell, 1925). In the invertebrates, however, although it is known for a number of species that one or both of these two factors are operative, our knowledge of the whole question is fragmentary. Both an accumulation of carbon dioxide...

Among its diverse biological actions, the vasoactive peptide bradykinin (BK) induces the transcription factor AP-1 and proliferation of mesangial cells (S. S. El-Dahr, S. Dipp, I. V. Yosipiv, and W. H. Baricos. Kidney Int. 50: 1850-1855, 1996). In the present study, we examined the role of protein tyrosine phosphorylation and the mitogen-activated protein kinases, ERK1/2,in mediating BK-induced...

abu mansoor thaalabi refers to three royal courts of his era in his book “yatimat al-dahr”: harun-al-rashid in baghdad, sayf-al-dawla al-hamadani in aleppo, and sahib-ibn abbad in rey. the first was a caliph, the second a king, and the third a vizier. the charisma and generosity of these three figures attracted a huge number of scholars, poets, writers and artists, which led to cultural and sci...

With the development of wireless technologies, autonomously distributed wireless ad hoc networks have attracted much research interest. In such networks, infrastructures such as base stations and wired connections are not necessary, and mobile terminals can directly exchange information to each other by relaying data packets. However, data are transmitted by the multihop relaying, and the wirel...

Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA E-mail: [email protected] The philosophy of Yin (阴) and Yang (阳) formed in ancient China describes a subtle, complementary, and sometimes intimate relationship between two opposites. This thousands of years old philosophy is, however, perfectly suited to descri...

This study explores the influence of user-generated content (UGC) on consumers’ post-purchase information process when a service failure occurs. Fairness theory, which regards counterfactual thinking (CFT) and judgments of blame as two key constructs in processing negative experiences, is applied in this study. In a scenario-based experimental study, the presence of UGC (positive, negative, or ...

The ultramafic portions of the Proterozoic ophiolite, Eastern Desert, Egypt, contain significant chromitite concentrations that are mainly located in the central and southern parts of the Eastern Desert as small and irregular bodies within a fully serpentinized dunite and harzburgite. Chromitite spinel exhibits a wide range of composition from high Cr to high Al varieties. The Cr# of chromian s...