The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the intestine and liver that rapidly metabolizes DAC into inactive uridine counterparts, severely limiting...

Dual-axis confocal (DAC) microscopy has been found to exhibit superior rejection of out-of-focus and multiply scattered background light compared to conventional single-axis confocal microscopy. DAC microscopes rely on the use of separated illumination and collection beam paths that focus and intersect at a single focal volume (voxel) within tissue. While it is generally recognized that the res...

An accurate behavioral model of a DAC-embedded opamp (DAC-opamp) is developed for a yield-ensuring LCD column driver design. A lookup table for the V-I curve of the unit differential pair in the DAC-opamp is extracted from a circuit simulation and is later manipulated through a random error insertion. Virtual ground assumption simplifies the output voltage estimation algorithm. The developed be...

Treatment with doxorubicin (Dox) results in serious systemic toxicities that limit effectiveness for cancer treatment and cause long-term health issues for cancer patients. We identified a new DNA aptamer to prostate-specific membrane antigen (PSMA) using fixed sequences to promote Dox binding and developed dimeric aptamer complexes (DACs) for specific delivery of Dox to PSMA(+) cancer cells. D...

BACKGROUND Co-administration of two or more antimicrobials with anti-anaerobic activity is not recommended except in certain circumstances. We therefore conducted an intervention to reduce unnecessary double anaerobic coverage (DAC) prescription. MATERIALS AND METHODS The intervention consisted of education using an institutional intranet and prospective audits and feedback provided through c...

This research work proposes new concepts of flexibility and self-correction for currentsteering digital-to-analog converters (DACs) which allow the attainment of broad functional and performance specifications, high linearity, and reduced dependence on the fabrication processes. This work analytically investigates the DAC linearity with respect to the accuracy of the DAC unit elements. The main...

This paper focuses on Design and Implementation of 10 Bit, 2MS/s successive approximation Register (SAR) Analog to digital converter (ADC) using Split DAC architecture. This SAR ADC architecture is designed and simulated using GPDK 0.18um CMOS technology. It consists of different blocks like sample and hold, comparator, Successive Approximation Register (SAR) and Split Digital to analog convert...

In this paper we formulate a novel Divide-andCoordinate (DaC) algorithm, the so-called Egalitarian Utilities Divide-and-Coordinate (EU-DaC) algorithm. The Divide-andCoordinate (DaC) framework [3] is a family of bounded DCOP algorithms that solve DCOPs by exploiting the concept of agreement. The intuition behind EU-DaC is that agents get closer to an agreement, on the optimal solution, when they...

Introduction Digital-to-analog converters (DACs) are usually used as an interface between digital systems and continuous analog circuitry. To choose the type of DAC best suited for an application, the designer must consider many important performance measures. • Resolution: Generally, a DAC is specified by the number of bits in the input, or the input width, which represents the number of volta...