We show that for each of the groups S3, D4, Q4, Z4 x Z2 and D6 the necessary conditions are sufficient for the existence of a generalized Bhaskar Rao design. That is, we show that: (i) a GBRD (v, 3, λ; S3) exists if and only if λ ≡ O (mod 6 ) and λv(v 1) ≡ O(mod 24); (ii) if G is one of the groups D4, Q4, and Z4 x Z2, a GBRD (v, 3, λ; G) exists if and only if λ ≡ O(mod 8) and λv(v 1) ≡ O(mod 6)...

One of the important targets of dopamine D4 receptors in prefrontal cortex (PFC) is the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII). In the present study, we investigated the effect of D4 receptor activation on subcellular localization of CaMKII. We found that activation of D4 receptors, but not D2 receptors, induced a rapid translocation of alpha-CaMKII from cytosol to...

The dopamine D4 receptor in prefrontal cortex (PFC) plays a key role in normal mental functions and neuropsychiatric disorders. However, the cellular mechanisms and physiological actions of D4 receptors remain elusive. In this study, we found that activation of D4 receptors in PFC exerts a complex regulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII), a multifunctional enzyme criti...

This study compared the therapeutic efficacy of levofloxacin, ornidazole and alpha tocopherol combination and prostaglandin F2α (PGF2α) in longstanding cases of endometritis and evaluated their impact on Interleukin-6 (IL-6) and Interleukin-10 (IL-10) transcript level in peripheral blood leukocytes. Eighteen endometritic crossbred Jersey cows were randomly al...

The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was measured using reverse transcription-quantitative polymerase chain reaction (RT-qP...

BACKGROUND This study was aimed to assess the effects of angiotensin II (Ang II) supplementation to the In Vitro Maturation (IVM) and In Vitro Culture (IVC) media of vitrified-warmed ovine oocytes on their developmental competence and expression of Na(+)/K(+)/ATPase in resulting embryos. METHODS The slaughterhouse-derived immature oocytes (n=1069) were randomly distributed into four experimen...

Background: IL-4 is a cytokine that induces differentiation of naive helper T cells into Th2 cells. Once activated by IL-4, Th2 cells subsequently produce additional IL-4. Objective: To examine the effect of IL-4 on IL-17 production and its effect in Collagen- Induced Arthritis (CIA) mice. Method: In this study, a chicken collagen-II-induced experimental arthritis (CIA) model was used in DBA/1 ...

Background: Intestinal inflammation, dysbiosis, intestinal permeability (IP) and bacterial translocation (BT) have been identified in patients with spondyloarthritis but the time at which they appear their contribution to pathogenesis of disease is still a matter debate. Objectives: To investigate time-course IP BT rat model reactive arthritis, subgroup SpA, adjuvant-induced arthritis model. Me...

Present investigation was carried out to identify DNA polymorphism of IL-2Rγ and ChB6 genes. Sixty five birds belonging to the indigenous chicken of Himachal Pradesh were utilized. Good quality DNA samples were subjected to PCR-RFLP analysis using chicken specific primers. Overnight restriction enzyme digestion was carried out at 37°C with IU Hph I and Pvu II for IL-2Rγ and ChB6 genes, respecti...

A field experiment was conducted to examine the effects of different depths ofnitrogen (N) fertiliser placements on N accumulation, remobilisation and NO3−-Ncontent in soil of rainfed wheat. Nitrogen was applied on the surface (D1) and inthe 10 cm (D2), 20 cm (D3) and 30 cm (D4) soil layers from 2010 to 2012.Compared with D1 and D2, D3 and D4 treatments obtained significant higher Ndistribution...