3 Find-Intersection Query 4 3.1 Constructing Intersection Points . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.1.1 Case d4 6= 0 and e(x̄) 6= 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3.1.2 Case d4 6= 0 and e(x̄) = 0 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3.1.3 Case d4 = 0, d2 6= 0, and e2 6= 0 . . . . . . . . ....

The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was measured using reverse transcription-quantitative polymerase chain reaction (RT-qP...

One of the important targets of dopamine D4 receptors in prefrontal cortex (PFC) is the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII). In the present study, we investigated the effect of D4 receptor activation on subcellular localization of CaMKII. We found that activation of D4 receptors, but not D2 receptors, induced a rapid translocation of alpha-CaMKII from cytosol to...

Octamethylcyclotetrasiloxane (D4) and decamethylpentasiloxane (D5) are used as ingredients for personal care products (PCPs). Because of the use of these PCPs, consumers are exposed daily to D4 and D5. A sensitive analytical method was developed for analysis of D4 and D5 in end-exhaled air by thermal desorption gas chromatography mass spectrometry (TD-GC-MS), to determine the internal dose for ...

Polymorphic variants of the dopamine D4 receptor gene (DRD4) have been repeatedly associated with numerous neuropsychiatric disorders. Yet, the functional role of the D4 receptor and the functional differences of the products of DRD4 polymorphic variants remained enigmatic. Immunohistochemical and optogenetic-microdialysis experiments were performed in knock-in mice expressing a D4 receptor wit...

The dopamine D4 receptor in prefrontal cortex (PFC) plays a key role in normal mental functions and neuropsychiatric disorders. However, the cellular mechanisms and physiological actions of D4 receptors remain elusive. In this study, we found that activation of D4 receptors in PFC exerts a complex regulation of Ca2+/calmodulin-dependent protein kinase II (CaMKII), a multifunctional enzyme criti...

Pulmonary vascular responses to leukotriene D4 were investigated in the intact-chest animal under conditions of controlled pulmonary blood flow. Intralobar injections of leukotriene D4 in the sheep caused dose-dependent increases in lobar arterial and small vein pressures without influencing left atrial or systemic arterial pressure. Leukotriene D4 was very potent in increasing pulmonary vascul...

A bstract We construct a supergravity background corresponding to backreacted D0/D4-brane system. The is holographically dual the Venecianno limit of Berkoos-Douglas matrix model. It known that localized D0/D4 system unstable when D0-branes are within D4-branes. To circumvent this difficulty we separate D4s from D0s, which placed at origin, and restore symmetry combined by distributing D4-brane...

A pharmacophore model for dopamine D4 antagonists has been developed on the basis of a previously reported dopamine D2 model. By using exhaustive conformational analyses (MM3* force field and the GB/SA hydration model) and least-squares molecular superimposition studies, a set of eighteen structurally diverse high affinity D4 antagonists have successfully been accommodated in the D4 pharmacopho...