نتایج جستجو برای: d24 o14
تعداد نتایج: 576 فیلتر نتایج به سال:
در تحلیل نئوکلاسیکی رفتار تولیدکننده، فرض می شود تولیدکنندگان با ترکیب بهینه عوامل تولید و حداقل سازی هزینه ها به دنبال کسب بیشترین سود هستند. پیش فرض این رفتار، وجود قیمت های بازاری است که در بازار رقابتی و فارغ از دخالت نیروهای غیربازاری شکل می گیرند و به عنوان معیاری از کمیابی عوامل تولید، عمل می کنند. اگر به دلیل انحرافات قیمتی، قیمت ها راهنمای غلطی باشند، در این صورت، نهاده ها به صورت ناکا...
Studies have demonstrated that oncolytic adenoviruses based on a 24 base pair deletion in the viral E1A gene (D24) may be promising therapeutics for treating a number of cancer types. In order to increase the therapeutic potential of these oncolytic viruses, a novel conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an Ad5/3 fi...
Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms control enzyme function at significantly shorter time-scales compared to the long-term effects of metabolic reprogramming on cell proliferation. It remains unclear if and how the speed and reversibility afforded by rapid allosteric control of m...
Nonalcoholic fatty liver disease (NAFLD) can develop into end-stage disease that includes cryptogenic cirrhosis and hepatocellular carcinoma. Bacterial endotoxin, for example lipopolysaccharide (LPS), plays an important role in the pathogenesis of NAFLD. The aim of this study was to assess the role of LPS in the development of NAFLD. Twenty-one male Zucker (fa/fa) rats were divided into three g...
Sarcomas are a relatively rare cancer, but often incurable at the late metastatic stage. Oncolytic immunotherapy has gained attention over the past years, and a wide range of oncolytic viruses have been delivered via intratumoral injection with positive safety and promising efficacy data. Here, we report preclinical and clinical results from treatment of sarcoma with oncolytic adenovirus Ad5/3-...
BACKGROUND Clinacanthus nutans (Burm. f.) Lindau leaves are widely used by cancer patients and the leaf extracts possess cytotoxic and antiproliferative effects on several human cancer cell lines. However, the effect of C. nutans leaf extract on human melanoma, which is the least common but most fatal form of skin cancer and one of the most common cancers diagnosed in both sexes worldwide, is u...
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