During the process of HIV-1 fusion with the target cell, the N-terminal heptad repeat (NHR) of gp41 interacts with the C-terminal heptad repeat (CHR) to form fusogenic six-helix bundle (6-HB) core. We previously identified a crucial residue for 6-HB formation and virus entry--Lys63 (K63) in the C-terminal region of NHR (aa 54-70), which forms a hydrophobic cavity. It can form an important salt ...

Crashworthiness studies are in high demand for designing transportation systems. Energy absorption capability in vehicle collisions is an important parameter for the development of passive safety systems dealing with the protection of passengers and cargo departments in the event of an accident. Protective structures, which contribute significantly to the crashworthiness capability of automotiv...

The spatial organization of eukaryotic cells depends on a regulated cytoskeleton and motor proteins that use it as tracks for cargo transport and delivery. The major motor proteins implicated in cargo transport are the kinesins and dyneins that use microtubule tracks and unconventional myosins, most notably myosin Vs, which use actin filaments. The delivery cycle of transporting motors must be ...