Partial monosomy 21 (PM21) is a rare chromosomal abnormality that is characterized by the loss of a variable segment along human chromosome 21 (Hsa21). The clinical phenotypes of this loss are heterogeneous and range from mild alterations to lethal consequences, depending on the affected region of Hsa21. The most common features include intellectual disabilities, craniofacial dysmorphology, sho...

This study aims to observe the expression of microRNA (miR)-634 in different gastric cancer cell lines and tissues, and to study the effects of miR-634 on the proliferation, migration, and invasion of the gastric cancer cells. The miR-634 mimics and miR-634 inhibitors were transfected by lentivirus into human gastric cancer SGC-7901 and MGC-803 cells, and the miR-634 cells without transfection ...

Digital microfluidics (DMF), a fluid-handling technique in which picolitre-microlitre droplets are manipulated electrostatically on an array of electrodes, has recently become popular for applications in chemistry and biology. DMF devices are reconfigurable, have no moving parts, and are compatible with conventional high-throughput screening infrastructure (e.g., multiwell plate readers). For t...

the political approach of shaykh zāhid gīlānī paved the way for shaykh ṣafī al-dīn ardabīlī’s political thinking and his closeness to the power-holders of the time. in addition to acquiring the rules and manners of sufism, shaykh ṣafī al-dīn learned from his master the political approaches for expanding his sufi order, as well. these approaches turned into a political movement in the safavid or...

Osteoarthritis (OA) is a degenerative disease characterized by deterioration of articular cartilage. Recent studies have demonstrated the importance of some microRNAs in cartilage damage. The aim of this study was to identify and characterize the expression of microRNA-634 (miR-634) in normal and OA chondrocytes, and to determine its role in OA pathogenesis. Human normal and OA chondrocytes obt...

Glioma is the most common intracranial malignant tumors, accounting for about 40% of intracranial tumors. Primary or secondary drug resistance is one of the main reasons for the failure of treatment. The oncogenic or tumor-suppressive roles of miR-634 have been revealed in different types of cancer. However, the role of miR-634 in glioma remains unknown and whether miR-634 could sensitize gliom...

http://bmj.com/cgi/content/full/328/7440/634 Updated information and services can be found at: These include: Data supplement http://bmj.com/cgi/content/full/328/7440/634/DC1 "Categories of strength used in statements" References http://bmj.com/cgi/content/full/328/7440/634#otherarticles 29 online articles that cite this article can be accessed at: http://bmj.com/cgi/content/full/328/7440/634#B...

BACKGROUND The multiple endocrine neoplasia 2 (MEN 2) syndromes [MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC)] are caused by germline mutations of the RET protooncogene. Because 85% of MEN 2A patients and 30% of FMTC patients have mutations at codon 634, the recommended molecular analyses begin at exon 11, where codon 634 is located. METHODS We scanned codon 634 of the RET ...

khwaja nasīr al-dīn tūsī is accused, by many, of collaborating with the mongol invaders and legitimizing their domination (power). using the identity theory of manuel castells and discourse theory, the present essay hypothesizes that khwaja nasīr has tried to create iranian identity utilizing the archetypes of iranshahr and has founded a programmed identity that was later followed by other bure...

khwāja naṣīr al-dīn ṭūsī is one of the greatest thinkers of the middle centuries (ah), who enjoys a high status in science and literature and has a worldwide reputation. naṣīr al-dīn ṭūsī did not suffice himself merely with science (‘ilm) and thought and was involved in practical politics, too. the last two decades of khwāja naṣīr’s life in ilkhanids courts was his period of scientific and prac...