Despite recent developments, the gap between Eastern and Western Europe childhood cancer survival rates and quality of care often persists. This one-year program aims to improve the quality of life of children suffering from cancer and reduce the burden of childhood cancer in four countries of CEE (CzR, Hu, Ro, Pol) via better coordination of medical and psychosocial care. Through a practice-or...

OBJECTIVES This retrospective survey assessed the clinical survival of zirconia-based crowns (PFZ) and conventional porcelain- fused-to-metal (PFM) crowns on posterior teeth in private practice. METHOD AND MATERIALS A print survey of 13 private practitioners was conducted to assess the long-term survival of previously placed full-coverage crowns. The practitioners reported a total of 2,182 pr...

Lysinibacillus sphaericus strain OT4b.31 is a native Colombian strain having no larvicidal activity against Culex quinquefasciatus and is widely applied in the bioremediation of heavy-metal polluted environments. Strain OT4b.31 was placed between DNA homology groups III and IV. By gap-filling and alignment steps, we propose a 4,096,672 bp chromosomal scaffold. The whole genome (consisting of 4,...

Staphylococcus aureus CzrA and Mycobacterium tuberculosis NmtR are homologous zinccobalt-responsive and nickelcobalt-responsive transcriptional repressors in vivo, respectively, and members of the ArsRSmtB superfamily of prokaryotic metal sensor proteins. We show here that Zn(II) is the most potent negative allosteric regulator of czr operatorpromoter binding in vitro with the trend Zn(II)>Co(I...

Staphylococcus aureus CzrA is a zinc-dependent transcriptional repressor from the ubiquitous ArsR family of metal sensor proteins. Zn(II) binds to a pair of intersubunit C-terminal alpha5-sensing sites, some 15 A distant from the DNA-binding interface, and allosterically inhibits DNA binding. This regulation is characterized by a large allosteric coupling free energy (DeltaGc) of approximately ...

Celem artykułu naukowego jest zbadanie zastosowania modeli elastyczności w zarządzaniu uczelniami zgodnie z celami Zrównoważonego Rozwoju. Artykuł uzasadnia konieczność stosowania szkoły wyższej. analizuje główne „Cele Rozwoju: Ukraina”, przedstawia wizję wytycznych dla osiągnięcia przez Ukrainę Celów Rozwoju (CZR), które zostały zatwierdzone na Szczycie ONZ 2015 roku. Na podstawie wyników anal...

Ultra-performance liquid chromatography-tandem mass spectrometry was used to establish the cytokinin profile of the bryophyte Physcomitrella patens (Hedw.) B.S.G.; of 40 analyzed cytokinins, 20 were detected. cis-Zeatin-riboside-O-glucoside, N(6)-(Delta(2)-isopentenyl)adenosine-5'-monophosphate (iPRMP), and trans-zeatin-riboside-O-glucoside were the most abundant intracellular cytokinins. In ad...