background and objective: in addition to the use of chemicals in food, pharmaceutical, cosmetic and hygiene industries, use of herbal and natural compounds have also increased. it seems natural ingredients compared with the chemical components show less side effects, such as mutagenicity and carcinogenesis however, their use can also be associated with side effects and toxicity. some significan...

objective(s): chalcones and their rigid analogues represent an important class of small molecules having anticancer activities. therefore, in this study the synthesis and cytotoxic activity of new 3-benzylidenchroman-4-ones were described as rigid chalcone analogues.   materials and methods: the reaction of resorcinol with 3-chloropropionic acid in the presence of cf3so3h was afforded correspon...

purpose : cytotoxic drugs are the gold standard and the first line treatment for ophthalmological manifestations of behçet’s disease (bd). the purpose of this study was to evaluate the outcome of eyes with chlorambucil on long-term follow-up, in a longitudinal study on 15 years. methods : chlorambucil was given as 0.2 to 0.3 mg per kilogram of body weight and per day. prednisolone was concomita...

the genus stachys belongs to lamiaceae family with about 300 species and worldwide distribution. in the present study, the cytotoxic activity of four fractions of different satchys species (s. byzatina c. koch., s. inflata benth., s. setifera ten. and s. persica gmel.), has been investigated against ht-29 (colon carcinoma), caco-2 (colorectal adenocarcinoma), t-47d (breast ductal carcinoma) and...

background and objectives: cancer is a public health problem all over the world. herbal medicines have a vital role in the prevention and treatment of cancer and large numbers of plants and their isolated constituents have shown potential anticancer activity. methods: twenty seven medicinal plants from southern iran provinces have been extracted with methanol and screened for their cytotoxic ac...

objective(s):this study aims at exploring cytotoxic activity of different peptides derived from vsvg protein against mcf-7 and mda-mb-231 breast cancer cell lines and human embryonic kidney normal cell (hek 293).    materials and methods: the anticp web server was used to predict anticancer peptides. the cytotoxic activity of peptides with high score (p26, p7) and low score (p19) was examined b...

different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...

salvia is one of the largest genera of  lamiaceae family. several species of this genus are perfumed and wealthy in essential oils. some of them are used in industry, pharmacy and aromatherapy. they have shown different biological effects such as antibacterial and antioxidant activity. for the present study, salvia verticillata l. was collected from shahrestanak, mazandaran, iran. hydrodistille...

objective: homalium letestui pellegr (flacourtiaceae) is used in traditional medicine in parts of nigeria for the treatment of malaria, ulcer, and inflammatory diseases and as an aphrodisiac. this investigation was aimed to evaluate the cytotoxic, immunomodulatory, and antileishmanial properties of stem extract and fractions of homalium letestui (h. letestui). materials and methods: cytotoxic a...

background: achillea talagonica (asteraceae) is an endemic herbaceous plant in iran with small yellow flowers and several times pinnately divided leaves in worm shape. the plant was found to be cytotoxic in our previous studies.   materials and methods: a. talagonica was collected in may 2005 from talegan in north of iran during the full flowering stage. dried aerial parts of the plant were red...