نتایج جستجو برای: cytome assay

تعداد نتایج: 221732  

Journal: :Mutation research 2009
Michael Fenech

A brief account of an improbable career in the field of genetic toxicology is given, extending from my early years in Malta through a life-changing decision to study in Australia (Down Under). I describe the circumstances that led to the discovery of the cytokinesis-block micronucleus (CBMN) assay and its evolution into a cytome assay of chromosome breakage and loss (micronuclei), asymmetrical ...

Journal: :International journal of basic and clinical pharmacology 2023

Background: Thiomersal is used as a preservative of some vaccines or trace from the pathogen inactivation process in vaccine production. Prophylactic use paracetamol upon vaccination still common, even though decreases immune response on vaccines. Considering cytotoxic and genotoxic potential thiomersal possible interaction vivo, vitro study was performed. Methods: The effects combination were ...

Journal: :Mutation research 2011
Stefano Bonassi Erdem Coskun Marcello Ceppi Cecilia Lando Claudia Bolognesi Sema Burgaz Nina Holland Micheline Kirsh-Volders Siegfried Knasmueller Errol Zeiger Deyanira Carnesoltas Delia Cavallo Juliana da Silva Vanessa M de Andrade Gonca Cakmak Demircigil Aníbal Domínguez Odio Hamiyet Donmez-Altuntas Gilka Gattas Ashok Giri Sarbani Giri Belinda Gómez-Meda Sandra Gómez-Arroyo Valeria Hadjidekova Anja Haveric Mala Kamboj Kemajl Kurteshi Maria Grazia Martino-Roth Regina Montero Montoya Armen Nersesyan Susana Pastor-Benito Daisy Maria Favero Salvadori Alina Shaposhnikova Helga Stopper Philip Thomas Olivia Torres-Bugarín Abhay Singh Yadav Guillermo Zúñiga González Michael Fenech

The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and estimating a range of reference values are research priorities that will be addressed by the HUMN(XL) collaborative study. The HUMN(XL) project evaluates the impact of host factor...

2015
Noran Aboalela Debra Lyon R. K. Elswick Debra Lynch Kelly Jenni Brumelle Harry D. Bear Colleen Jackson-Cook Shian-Ying Sung

While advances in therapeutic approaches have resulted in improved survival rates for women diagnosed with breast cancer, subsets of these survivors develop persistent psychoneurological symptoms (fatigue, depression/anxiety, cognitive dysfunction) that compromise their quality of life. The biological basis for these persistent symptoms is unclear, but could reflect the acquisition of soma-wide...

2017
Sanjay Singh A. S. Yadav

The Buccal Micronucleus Cytome (BMCyt) in exfoliated buccal epithelial cells is a minimally invasive method for assessing chromosomal instability, DNA damage and cell death. It has been widely used in occupational and lifestyle related studies. For the present study 63 male subjects were taken out of which 32 were vegetarian and 31 subjects were nonvegetarian matched with respect to their age, ...

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