PURPOSE To propose an alternative hypothesis for the observed differential survival of patients with small, medium, and large choroidal melanomas based on recently uncovered cytogenetic evidence about melanocytic choroidal tumors. METHODS Review and analysis of published data. RESULTS Recent evidence has shown that recurring nonrandom cytogenetic abnormalities are present within virtually a...

Background Cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. Approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (RSAs). The aim of this study was to detect chromosome abnormalities in couples with RSAs and to compare our results with those reported previously. Materia...

BACKGROUND Although knowledge of the genetics of diffuse large B-cell lymphoma (DLBCL) has been increasing, little is known about the characteristics and prognostic significance of cytogenetic abnormalities and the clinical utility of cytogenetic studies performed on bone marrow (BM) specimens. To investigate the significance of isolated cytogenetic aberrations in the absence of histologic BM i...

background chromosomal aberrations are one of the most common causes of mental retardation (mr). objectives in this study, in order to identify the rate of chromosomal abnormalities in idiopathic mr, 50 mr patients at a charity center in hamadan, iran, were investigated. methods fifty mentally retarded male patients without specific chromosomal abnormalities (e.g., down syndrome, fragile x synd...

background: cytogenetic study of reproductive wastage is an important aspect in determining the genetic background of early embryogenesis. approximately 15 to 20% of all pregnancies in humans are terminated as recurrent spontaneous abortions (rsas). the aim of this study was to detect chromosome abnormalities in couples with rsas and to compare our results with those reported previously. materi...

objective: chromosomal aberrations are common causes of multiple anomaly syndromes. recurrent chromosomal aberrations have been identified by conventional cytogenetic methods used widely as one of the most important clinical diagnostic techniques. materials and methods: in this retrospective study, the incidences of chromosomal aberrations were evaluated in a six year period from 2005 to 2011 i...

BACKGROUND Conventional karyotype has an established role in myelodysplastic syndrome (MDS) and is included in the International Prognostic Scoring System (IPSS) for patient risk stratification and treatment selection. Although some chromosomal abnormalities have been well characterized, the significance of several miscellaneous, infrequent, single chromosomal abnormalities remains to be define...