In this study, the encapsulation mechanism of oxyresveratrol and β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) was studied. As this research shows, oxyresveratrol and two cyclodextrins (CDs) were able to form inclusion complexes in a 1:1 stoichiometry. However, the interaction with HP-β-CD was more efficient, showing up as higher encapsulation constant (KF) (35,864.72 ± 3415....

Abstract For many years, cyclodextrins (CDs) have been the object of attention for their capability improving stability, solubility and bioavailability numerous molecules interest, including drugs nutraceuticals. They low toxicity this reason employed different routes administration, oral, ocular, nasal parenteral. Among them, hydroxypropyl-?-cyclodextrin (HP-?-CD) is least toxic. Several physi...

OBJECTIVES To compare the ability of different cyclodextrin polysulphate (CDPS) derivatives to affect human articular cartilage cell metabolism in vitro. METHODS OA chondrocytes were cultured in alginate and exposed to 5 µg/ml of 2,3,6-tri-O-methyl-β-cyclodextrin (ME-CD), 2,3-di-O-methyl-6-sulphate-β-cyclodextrin (ME-CD-6-S), 2,6-di-O-methyl-3-sulphate-β-cyclodextrin (ME-CD-3-S), (2-carboxyet...

The slightly water-soluble flavonoid quercetin (QUE) and its inclusion with either beta-cyclodextrin (betaCD), hydroxypropyl-beta-cyclodextrin (HP-betaCD) or sulfobutyl ether-beta-cyclodextrin (SBE-betaCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes have been determined by phase-solubility measurements; in all cases ty...

In this study, inclusion complexes (IC) of three cyclodextrin derivatives (HP-β-CD, HP-γ-CD, and M-β-CD) with eugenol (essential oil compound) were formed in highly concentrated aqueous solutions and then transformed into self-standing functional nanofibrous webs by electrospinning. The improved aqueous solubility of eugenol was confirmed by phase solubility diagrams, in addition, the phase sol...

paracetamol is a sparingly soluble bitter tasting drug. it is widely used as an analgesic and antipyretic. complexation of drug with different cyclodextrins (?, ? and hp-?-cd) was attempted to improve solubility of paracetamol. during the drug excipient interaction studies, ?, ? cyclodextrins elicited analytical interference and showed considerable absorbance at ?max (243.5 nm) of paracetamol w...

This study presents improvement in solubility and dissolution rate of valsartan (VAL) using β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HP-βCD). Formation and characterization of solid inclusion complexes were investigated by DSC, FTIR, SEM, HNMR and in-vitro dissolution studies. Preparation method influenced physical properties of binary mixtures. Inclusion complexes obtained by co-...

Eplerenone, a BCS class II drug with low bioavailability and t1/2 of 3-6 hrs is primarily used to treat Congestive Heart Failure (CHF) hypertension. So, develop the biological performance solid dispersion along oral disintegrates was prepared by employing HP ?-Cyclodextrin ?-Cyclodextrin. Eplerenone dispersions were repared various carriers in varying ratios carrier respectively (0.5:1, 1:1 1.5...

Supercritical Assisted Atomization (SAA) has been used to micronize α-cyclodextrin (α-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD). The effect of some process parameters such as precipitation temperature and solute concentration in the liquid solution has been studied to evaluate their influence on morphology and size of precipitated particles. Cyclodextrins micronization has been obtained wi...

The objective of this study was to elucidate the effects of hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) on the in vitro stability of insulin. It was found that HP-beta-CD had positive effects on the stability of insulin in acid and base and under high temperature conditions. Furthermore, use of HP-beta-CD could also increase the stability of disulfide bonds which are important to the conforma...