2-Cyano-3-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)acrylamide (3) was synthesized in 90% yield from condensation of equimolar equivalents 1-phenyl-3-(thiophen-2-yl)-1H-pyrazole-4-carbaldehyde (1) and 2-cyanoacetamide (2) boiling ethanol under basic condition for 45 min. The structure 3 determined using NMR spectroscopy single crystal X-ray diffraction.

6-Formyl-7-hydroxy-5-methoxy-2-methylchromone on bromination yields the 8-bromo deriva­ tive or the 8-bromo-6-formyl-5,7-dihydroxy derivative depending on the reaction condition. Cyclization of both leads to the corresponding 3-acetyl-, 3-benzoyl-, 3-carboxamido-, 3-carbethoxybenzodipyran derivatives. The 3-acetylbenzodipyran derivative when treated with ethyl acetoacetate or ethyl cyanoacetate...

The Acylase "Amano" (AA)-catalyzed synthesis of valuable pyridin-2-ones via domino Knoevenagel condensation-Michael addition-intramolecular cyclization-oxidization reaction between aldehyde, cyanoacetamide and ethyl acetoacetate or cyclohexyl acetoacetate was developed in the sense of a one-pot strategy. Various aliphatic, aromatic and hetero-aromatic pyridin-2-ones could also be produced in th...

5-Formyl-6-aminopyrimidine-2,4-(1H, 3H)-dione (2) has been previously prepared fromcompound 1. Cyclocondensation reaction of compound 2 with cyanoacetamide gave substituted pyridopyrimidine 3. Also, compound 2 was condensed with p-amino acetophenone and hydrazine derivatives to give 5-([(4-acetylphenyl)imino]methyl)-6-aminopyrimidine (4) and 5-substituted carboaldehyde-6-amino pyrimidine deriva...

Nano-rice bran/TiCl4has been prepared from rice bran and TiCl4 in n-hexane as solvent. Thennanoricebran/TiCl4 has been introduced as a novel catalystfor the three component synthesis of pyrano[3,2-b] pyransfrom the simple one-pot reactionbetweenaryl aldehydes,cyanoacetamide and kojicacid.Cleanliness, an eco-friendly catalyst, simple methodology, short time, and excellent yields ofproducts are s...