The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

ion channels are responsible for control of cell function in excitable tissues such as heart and brain and also in organs and tissues traditionally thought to be non- excitable including liver and epithelium. in the present research, the effect of lead (pb2+) on ca2+ -dependent action potential and currents was studied in f77 neuronal soma membrane of helix aspersa. for this purpose, action pot...

this study examines votes, ideologies and goals of iran’s cultural-intellectual currents after the islamic revolution in order to describe their scale and type impacts on women rights in iran. in the first section, a theoretical explanation of the relationship between social currents and legal demands based on social realism approach along with viewpoints of scholars who believe in the correlat...

introduction: in the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. methods: in this study, ampa and nmda receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. resu...

the goal of this study was to determine the effects of the l-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fkv1.4δn), an n-terminal-deleted mutant of the ferret kv1.4 potassium channel. measurements were made using a two electrode voltage clamp technique with channels expressed stably in xenopus oocytes. the fkv1.4δn currents displayed...

background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

We investigate the phase structure of pure compact U(1) lattice gauge theory in 4 dimensions with the Wilson action supplemented by a monopole term. To overcome the suppression of transitions between the phases in the simulations we make the monopole coupling a dynamical variable. We determine the phase diagram and find that the strength of the first order transition decreases with increasing w...

the expressions of “esoteric” and “esotericism” have a wide range of meanings, however, they specifically apply to religious, mystical, and philosophical secret schools. in ancient greek world, i.e. before the hellenistic era, we come across some currents with esoteric tendencies. the various texts from this period show that the ancient greeks sought the source of the esoteric currents outside ...

We studied a behavior of monopole currents in the high temperature (deconfinement) phase of abelian projected finite temperature SU(2) QCD in maximally abelian gauge. Wrapped monopole currents closed by periodic boundary play an important role for the spatial string tension which is a nonperturbative quantity in the deconfinement phase. The wrapped monopole current density seems to be non-vanis...

The 2009 influenza pandemic highlighted the limited options available for scholarly publications to rapidly communicate research findings in a time of crisis. In response to the needs of the community, PLOS launched PLOS Currents: Influenza as a publication channel that would meet the need for swift publication of research during that influenza pandemic. PLOS Currents: Influenza allowed the pro...