This analysis, using data from the bortezomib-melphalan-prednisone (VMP) arm of the Phase III VISTA study, investigated whether increased cumulative bortezomib dose could improve overall survival (OS) in transplant-ineligible patients with previously untreated multiple myeloma. Median cumulative bortezomib dose received by the 340 patients was 39 mg/m(2); this was selected as the cut-off for de...

background: osteonecrosis (on) is known to be one of the most disabling complications following corticosteroid (cs) medications. however, evidence regarding risk of asymptomatic prevalence of on among different diseases and the impact of variable steroid regimens are conflicting. we aimed to determine the prevalence of on of femoral head in asymptomatic patients with systemic rheumatic diseases...

It has been suggested that the use of a cumulative technique to obtain bronchodilator dose-response curves will cause a greater response than a non-cumulative technique, because sequential doses of drug will penetrate further into the lung. To test this hypothesis we have compared cumulative and non-cumulative dose-response curves for inhaled isoprenaline in 10 subjects with stable asthma, meas...

PURPOSE To evaluate the cumulative dose at point A for three and four centimeters central shielding. MATERIAL AND METHODS The plans of external beam radiotherapy plus conventional intracavitary brachytherapy were performed. Three or four centimeters central shieldings (after 44 Gy) were applied to the standard whole pelvis irradiation. Additional intracavitary brachytherapy 4 × 7 Gy at point ...