Background: Acute pancreatitis is a common gastro-intestinal disease with varied etiology, presentations, management and outcomes. Over the years the management has evolved from surgical to conservative under intensive care setting. Here we have attempted to study various interventions in the management of acute pancreatitis and correlate clinical/radiological severity indices with likelihood o...

BACKGROUND The New York University- New York City Health and Hospitals Corporation (NYU-HHC) Clinical and Translational Science Institute (CTSI) used a community-based participatory research (CBPR) and consensus-building approach among its community advisory board (CAB) and steering committee (SC) members to formulate research priorities to foster shared research collaborations. METHODS The D...

BACKGROUND AND PURPOSE The aim of CT-guided CTSI is to inject medication into the foraminal region where the nerve root is inflamed. The optimal location for needle placement and therapeutic delivery, however, remain uncertain. The purpose of this study was to investigate how needle positioning and angle of approach impact the transforaminal distribution of injectate. MATERIALS AND METHODS We...

Funding/Support:DrMangurian is supported by Career Development Award K23MH093689 from the National Institutes of Health (NIH), by the UCSF (University of California, San Francisco) Hellman Fellows Award for Early-Career Faculty, and by UCSF–Clinical and Translational Science Institute (UCSF-CTSI) grant UL1 TR000004 from the National Center for Advancing Translational Sciences (NCATS), NIH. Ms C...

Maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI) belong to human intestinal alpha-glucosidase and their N-terminal side catalytic domains are called NtMGAM and NtSI, and their C-terminal side catalytic domains are called CtMGAM and CtSI. As an antidiabetic, alpha-glucosidase inhibitor is required to bind to all of these domains to inhibit disaccharides hydrolysis. Salacinol and kotalanol...

BACKGROUND This study was undertaken to determine the prevalence of organ failure and its risk factors in patients with severe acute pancreatitis (SAP). METHODS A retrospective analysis was made of 186 patients with SAP who were had been hospitalized in the intensive care unit of Jinzhong First People's Hospital between March 2000 and October 2009. The patients met the diagnostic criteria of ...

BACKGROUND A number of scoring systems are available to predict prognosis in acute pancreatitis (AP). The aim of the study was to compare extra-pancreatic inflammation on computed tomography (CT) (EPIC score) and renal rim sign with clinical scores (BISAP, SIRS) and conventional CT severity index (CTSI) and modified CTSI (MCTSI) in predicting persistent organ failure (POF), intervention and mor...

BACKGROUND/AIMS To evaluate whether morphologic features on computed tomography (CT) correlate with outcome of patients with severe acute pancreatitis (SAP). METHODS 80 patients with SAP requiring percutaneous drainage therapy were retrospectively analyzed. Twelve CT features beyond the CT severity index (CTSI) were studied. Endpoints for patient outcome were patient death, length of hospital...

There is growing appreciation that process improvement holds promise for improving quality and efficiency across the translational research continuum but frameworks for such programs are not often described. The purpose of this paper is to present a framework and case examples of a Research Process Improvement Program implemented at Tufts CTSI. To promote research process improvement, we develo...

Introduction: Diseases of the pancreas have a very variable presentation and hence imaging plays an important role in the diagnosis and management of pancreatic disease, especially in acute pancreatitis. Computed tomography (CT) is the modality of choice as an evaluation of the pancreas. Materials and Methods: A total of 30 patients who were clinically suspected of having acute pancreatitis att...