INTRODUCTION The urinary level of the type II collagen degradation marker CTX-II is increased in postmenopausal women and in ovariectomised rats, suggesting that oestrogen deprivation induces cartilage breakdown. Here we investigate whether this response to oestrogen is also true for other type II collagen turnover markers known to be affected in osteoarthritis, and whether it relates to its pr...

BACKGROUND Animal studies of arthritis have suggested that bisphosphonates may have chondroprotective abilities. OBJECTIVE To evaluate the effect of bisphosphonate treatment on cartilage degradation. METHODS Type II collagen is almost exclusively localised in cartilage, where it is the major structural component of the tissue. Hence fragments derived from this protein should represent a spe...

In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal propeptides of type II procollagen (CPII), N‑terminal telopeptide...

Bone turnover markers (BTM) are gaining ground in clinical practice but to fully use their potential there is a need for establishing valid reference intervals (RI). Consequently, the purpose of study was establish general RI as well suggested carboxy-terminal cross-linked telopeptide type I collagen (β-CTX), pro-collagen N-terminal propeptide (PINP), osteocalcin (OC) and bone-specific alkaline...

background: micropatterning is becoming a powerful tool for studying cells in vitro. this method not only uses very small amount of material but also mimic the microenvironment structure present in living tissues better than flask culturing techniques. in previous studies using micropatterning of extracellular matrix proteins on glass surfaces, the rate of protein detachment from the surface wa...

OBJECTIVE Monitoring of bone disease in multiple myeloma is becoming increasingly important because bone-protecting treatment with bisphosphonate is becoming restricted after the awareness of osteonecrosis of the jaw. Despite the potential of biochemical markers of bone remodeling to monitor dynamic bone turnover, they are not used in everyday practice. Here, we investigate their usefulness to ...

Background It is known that there are biochemical markers of cartilage and bone tissue destruction, which reflect the metabolic processes occurring in tissues. For example, rheumatoid arthritis (RA), routine such as CTX-I, a degradation marker (C-terminal telopeptide type I collagen) CTX-II, II collagen), can be used. Also, to assess state tissue, determination collagen fragments by Urine Carti...

Bone turnover markers (BTM) are gaining ground in clinical practice but to fully use their potential there is a need for establishing valid reference intervals (RI). Consequently, the purpose of study was establish general RI as well suggested carboxy-terminal cross-linked telopeptide type I collagen (?-CTX), pro-collagen N-terminal propeptide (PINP), osteocalcin (OC) and bone-specific alkaline...

PURPOSE To determine the levels of bone and cartilage turnover markers in men with ankylosing spondylitis (AS) and to investigate their associations with disease activity, bone mineral density, and radiographic damage of the spine. PATIENTS AND METHODS This cross-sectional study enrolled 35 men with newly diagnosed AS. The bone mineral densities (BMD) of their lumbar spines and proximal femur...

PURPOSE Deoxypyridinoline (DPD) is a derivative of hydroxypyridinium, which is released during bone resorption into the blood stream and is eliminated unmodified with urine. A further collagen-derived marker of bone resorption is the C-terminal telopeptide of type I collagen (beta-CTX-I, here abbreviated as CTX), which is released in bone resorption and almost entirely excreted by the kidneys. ...