BACKGROUND Decrease of circulating tumor cells (CTC) during treatment is an independent prognostic factor in metastatic breast cancer (MBC). We specifically evaluated the impact of CTC on brain metastasis outcome. METHODS HER2-positive MBC with brain metastasis not previously treated with whole-brain radiotherapy received first-line combination of lapatinib and capecitabine in a phase II stud...

PURPOSE This study was aimed at detecting and characterizing circulating tumor cells (CTC) before and after neoadjuvant therapy (NT) in the peripheral blood of patients with breast cancer. EXPERIMENTAL DESIGN The clinical trial GeparQuattro incorporated NT approaches (epirubicin/cyclophosphamide prior to randomization to docetaxel alone, docetaxel in combination with capecitabine, or docetaxe...

Nowadays, several wireless communication solutions targeted at low-power devices (e.g. sensors, actuators) compete for market dominance. As a consequence, the deployment of Internet Things is slowed by fragmentation. However, Cross-Technology Communication (CTC) has appeared as solution capable bridging compatibility gap between non-interoperable devices. In this way, we propose using Wake-up R...

In March 2021, the American Rescue Plan substantially increased maximum per-child child tax credit (CTC). However, research has yet to explore educational investments associated with CTC. Thus, authors leverage a probability-based panel survey of CTC-eligible families across 49 states examine how parents’ in tutoring and college savings relate degree which parents believe that their children wi...

Although most research on cynicism toward change (CTC) has been conceptualized at the individual level, we propose that CTC is better conceptualized as a multilevel phenomenon, acting as both an employee attitude and an organizational climate. We conducted a multilevel investigation of CTC in a field sample of 687 correctional officers in the 14 prisons in a state penal system. Consistent with ...

wnloaded pose: This study aimed to detect the M30 neoepitope on circulating tumor cells (CTC) as a tool for ifying apoptotic CTC throughout disease course and treatment. erimental Design: An automated sample preparation and analysis platform for computing CTC earch) was integrated with a monoclonal antibody (M30) targeting a neoepitope disclosed by e cleavage at cytokeratin 18 (CK18) in early a...

BACKGROUND Endocrine therapy (ET) fails to induce a response in one half of patients with hormone receptor (HR)-positive metastatic breast cancer (MBC), and almost all will eventually become refractory to ET. Circulating tumor cells (CTC) are associated with worse prognosis in patients with MBC, but enumeration alone is insufficient to predict the absolute odds of benefit from any therapy, incl...

OBJECTIVE The aim of this study was to investigate the correlation between the efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and circulating tumor cell (CTC) levels in patients with advanced non-small cell lung cancer (NSCLC). The efficacy of EGFR-TKIs in reducing CTC counts in patients with advanced NSCLC was studied. PATIENTS AND METHODS A total of 66 pat...

BACKGROUND Early predictive markers for response are needed for advanced colorectal cancer (ACC) patients. We assessed the value of circulating tumour cells (CTC) in ACC patients treated with chemotherapy plus targeted agents (CAIRO2 phase III trial) and compared the results with computed tomography (CT) imaging. MATERIALS AND METHODS CTC were determined at baseline and at different time poin...

Circulating tumor cells (CTC) are useful in early detection of colorectal cancer. This study described a newly developed platform, integrated subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH), to assess CTCs in colorectal cancer. CTCs were detected by SE-iFISH in 40 of 44 preoperative colorectal cancer patients, and yielded a sensitivity of 90.9%, which was...