The effect of uni- and bilateral cryptorchidism on testicular inhibin and testosterone secretion and their relationships to gonadotropins were studied in rats. Mature Wistar male rats weighing approximately 300 g were made either uni- or bilaterally cryptorchid. Testicular inhibin and testosterone content and plasma levels of LH and FSH were examined 2 weeks later. A similar remarkable decrease...

Department of Urology, Renji Hospital, Shanghai Human Sperm Bank, Shanghai Jiao Tong University School of Medicine, Shanghai 200135, China; State Key Laboratory of Oncogenes and Related Genes, Stem Cell Research Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Shanghai Key Laboratory of Reproductive Medicine, Shanghai 200025, China; Shanghai Key...

INTRODUCTION Evidence collected over the years has demonstrated that cryptorchidism is associated with a defect in spermatogenesis and, as a consequence, with either reduced fertility or infertility. However, the effect of cryptorchidism on Leydig cell function is less clear. The aim of our study therefore was to investigate the regulation of steroid hormone biosynthesis and, additionally, inte...

GOAL The goal of this study was to determine relationship between the sensitivity and specificity of testicular volume (TV) and testicular atrophy index (TAI) in the indirect assessment of functional ability of cryptorchid testicles. MATERIAL AND METHODS The study included sixty children with unilateral cryptorchidism who were treated surgically at the Clinic of Pediatric Surgery, Clinical Ce...

OBJECTIVE Testicular cell transplantation has been widely used to investigate the restoration of fertility in rodent models. In this research we apply transplantation as a treatment method in the cryptorchid model and compare this method with orchidopexy, which is the routine treatment for this problem. We studied the controversial effects of treatment on the number of germ cells and other morp...

BACKGROUND Cryptorchidism is a common malformation in neonates; surgery or medical treatments are applied during childhood. Untreated cryptorchid testes are in the risk of intratubular germ cell neoplasia (IGCN) and consequently invasive testicular tumors which could be shown by immunohistochemistry staining for placental like acid phosphatase (PLAP) marker. OBJECTIVE We designed this study t...

Pituitaries were collected from intact rams and rams that had been rendered bilaterally cryptorchid by surgery to examine the effects of cryptorchidism on gonadotropin heterogeneity, levels of uncombined luteinizing hormone (LH) subunits, and the apparent molecular sizes of LH and follicle-stimulating hormone (FSH). Cryptorchid rams had higher pituitary contents of LH and FSH as well as reduced...

BACKGROUND The aim of the present study is to make a comparative study in human fetuses and in patients with cryptorchidism, analyzing the incidence of a number anomalies of the testes for both populations. METHODS We studied 326 testes from 163 human fetuses ranging in age from 10 to 35 weeks postconception (WPC) and 133 testes from 101 cryptorchid patients aged from 1 to 15 years old (mean,...

The human testis is composed of seminiferous tubules and interstitium. Within the interstitium, residing Leydig cells can occasionally bear Reinke ́s crystals. The aim of the current study was to investigate Reinke ́s crystals in perivascular and peritubular Leydig cells in control and infertile (cryptorchid) testes. For that purpose, bright field, confocal and transmission electron microscopy we...

A clinical case of acquired unilateral cryptorchidism after herniotomy was described. Extensive degenerative changes were histologically observed not only in the cryptorchid testis but also in the scrotal one, and were regarded as underlying processes of sterility in the case of unilateral cryptorchidism . In experimental unilateral cryptorchidism in dogs, histologically demon strable spermatog...