Creutzfeldt-Jakob disease is increasingly being reported in the last three decades as a result of increased awareness for the disease. Various studies have reported an annual incidence of 0.5-1.5 cases of Creutzfeldt-Jakob disease per million of general population. However, in our country, like other developing countries, the disease is still under-reported. Herewith, we described our clinical ...

1. Mehndiratta MM, Bajaj BK, Gupta M et al : Creutzfeldt-Jacob disease : Report of 10 cases from North India. Neurol India 2001; 49 : 338-341. 2. Shankar SK, Satish Chandra P : Creutzfeldt-Jacob disease – Cases in India in 30 years (1968-1997). CJD Registry NIMHANS, Bangalore, India. 3. Singhal BS, Dastur DK : Creutzfeldt – Jacob Disease in Western India. Observation in 7 patients. Neuroepidemi...

Creutzfeldt-Jakob disease (CJD) is presumably caused by a slow infectious pathogen or prion. The principal clinical features of Creutzfeldt-Jakob disease are dementia, pyramidal and extrapyramidal symptoms and signs, cerebellar dysfunction, and myoclonus. The patient rapidly deteriorates, declines to a vegetative state, becomes comatous, and is ultimately dead within several months. The authors...

OBJECTIVE To describe the early psychiatric and neurological features of variant Creutzfeldt-Jakob disease. DESIGN Cohort study. SETTING National surveillance system for Creutzfeldt-Jakob disease in the United Kingdom. PARTICIPANTS The first 100 cases of variant Creutzfeldt-Jakob disease identified in the United Kingdom. MAIN OUTCOME MEASURES The timing and nature of early psychiatric a...

BACKGROUND We report a novel case of a rare disease: spontaneous Creutzfeldt-Jakob disease in a patient with well-controlled HIV. We explore the relationship between spontaneous Creutzfeldt-Jakob disease and HIV. CASE REPORT A 66-year-old man with long-standing, well-controlled HIV infection presented with 3 months of progressive, subacute neurocognitive decline. His symptoms included concept...

OBJECTIVES Among the classification criteria for the diagnosis of Creutzfeldt-Jakob disease, akinetic mutism is described as a symptom which helps to establish the diagnosis as possible or probable. Akinetic mutism has been anatomically divided into two forms--the mesencephalic form and the frontal form. The aim of this study was to delimit the symptom of akinetic mutism in patients with Creutz...

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creutzfeldt-jacob disease is a prion disease which has a wide range of clinical presentations. its diagnosis is not simple and clinical manifestation along with eeg, mr imaging findings and cerebrospinal fluid (csf) analysis should be considered for a definite diagnosis. a-50-year-old woman referred with cognitive impairment, myoclonic jerks, mutism and difficulty in swallowing to our clinic. e...

We serially examined a patient with Creutzfeldt-Jakob disease using fludeoxyglucose F 18 and positron emission tomography. Marked cerebral hypometabolism reflected clinical deterioration in the early stages of Creutzfeldt-Jakob disease when no parenchymal abnormalities were present on MR imaging.

Creutzfeldt-Jakob disease is a very rare, progressive neurodegenerative disorder that is incurable and always fatal. It is one of the transmissible spongiform encephalopathies caused by prions. Multiple vacuoles in neuropil and neuronal loss in the gray matter gives the classical sponge-like appearance of brain and are responsible for the typical clinical symptoms. In this report, we present 4 ...