The specificity and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AM I) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chloride. Quantification of isolated MB was performed by creatine phosphokinase (...

Increasing interest in serum enzyme levels in various conditions has led to recognition of the value of the estimation of creatine phosphokinase activity in muscular disorders. Interpretation of the results obtained has been hampered by the lack of adequate information about the ;normal range'. Data for the normal levels of creatine phosphokinase in cord blood, children, and adults are presented.

2 Laporta MA, Linde HW, Bruce DL, Fitzsimons EJ. Elevation of creatine phosphokinase in young men after recreational exercise. JAMA 1978;239:2685-6. 3 Roberts R, Gowda KS, Ludbrook PA, Sobel BE. Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction. AmJr Cardiol 1975 ;36 :433-7. 4 Forster G, Bernt E, Bergmeyer HU. Creatine kinase. In: B...

OBJECTIVE The association between biochemical markers and left ventricular ejection fraction in patients with myocardial infarction was not completely studied. Our goal is to study the association between biochemical markers and left ventricular dysfunction in patients with ST-elevation acute myocardial infarction. METHODS With an observational and prospective design we included patients with...

Rhabdomyolysis constitutes an uncommon cause of acute kidney injury (AKI). A large variety causes with different pathogenic mechanisms may involve skeletal muscles resulting in rhabdomyolysis or without injury. Crush syndrome and unaccustomed physical exertion are the most common rhabdomyolysis. This study reports local cases AKI secondary to that presented a tertiary care centre over period fo...