The craniofacial skeleton is a complex and unique structure. The perturbation of its development can lead to craniofacial dysmorphology and associated morbidities. Our ability to prevent or mitigate craniofacial skeletal anomalies is at least partly dependent on our understanding of the unique physiological development of the craniofacial skeleton. Mouse models are critical tools for the study ...

synophthalmia is a form of cyclopia, in which some elements of two eyes are fused and form a single eye in the middle region of the forehead. the head of a holstein female calf born from a 5-year-old cow was referred to department of pathology, school of veterinary medicine, shahrekord university due to multiple congenital anomalies. the calf had been slaughtered immediately after birth due to ...

median cleft is the midline cleft of the lip. it develops due to incomplete or failed fusion of the median nasal prominence. it can present with minimal deformities such as involvement of the vermilion border, or complex clefting of the midline structures and brain. median clefts are broadly classified as true and false clefts. this case report describes a rare case of median cleft of the upper...

conclusions excellent esthetic and functional results achieved; total treatment duration was about 72 months. case presentation this is a case report about the successful orthodontic treatment of a patient with mild hemifacial microsomia (hfm), using a non-surgical orthopedic and orthodontic treatment approach. the aim of this approach was to make the best noninvasive modality to treat hfm. a 7...

distraction osteogenesis (do), firstly introduced to the medical world by russian scientist ilizarov for long bone lenghtening in orthopedics can be considered as an appropriate substitute in the treatment of maxillofacial deformities. natural events occuring during the repair of a fractured bone segment not only lead to the desired bone length but also prevent from the undesired disadvantages ...

fryns-aftimos syndrome is a rare autosomal dominant disorder characterized by craniofacial signs, anterior neuronal migration disorder (pachygyria, lissencephaly), skeletal deformities and mental retardation. we describe a five-year-old boy with abnormal facial features (hypertelorism, ptosis, high arched palate), skeletal problems (short stature, short fingers, flat feet) and mild intellectual...

Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases. Virtually all craniofacial structures are derivatives of mesenchymal cells. Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical division, and reside in various craniofacial structures in t...

We created the Ontology of Craniofacial Development and Malformation (OCDM) [1] to provide a unifying framework for organizing and integrating craniofacial data ranging from genes to clinical phenotypes from multi-species. Within this framework we focused on spatio-structural representation of anatomical entities related to craniofacial development and malformation, such as craniosynostosis and...

We introduce the Ontology of Craniofacial Development and Malformation (OCDM) as a mechanism for representing knowledge about craniofacial development and malformation, and for using that knowledge to facilitate integrating craniofacial data obtained via multiple techniques from multiple labs and at multiple levels of granularity. The OCDM is a project of the NIDCR-sponsored FaceBase Consortium...

Craniofacial registration is used to establish the point-to-point correspondence in a unified coordinate system among human craniofacial models. It is the foundation of craniofacial reconstruction and other craniofacial statistical analysis research. In this paper, a non-rigid 3D craniofacial registration method using thin-plate spline transform and cylindrical surface projection is proposed. F...