Burkholderia pseudomallei is the causative agent of melioidosis, a severe infection prominent in northern Australia and Southeast Asia. The "gold standard" for melioidosis diagnosis is bacterial isolation, which takes several days to complete. The resulting delay in diagnosis leads to delayed treatments, which could result in death. In an attempt to develop better methods for early diagnosis of...

With the exponential growth of cyber-physical systems (CPS), new security challenges have emerged. Various vulnerabilities, threats, attacks, and controls have been introduced for the new generation of CPS. However, there lack a systematic study of CPS security issues. In particular, the heterogeneity of CPS components and the diversity of CPS systems have made it very difficult to study the pr...

The specific activities of enzymes catalyzing the ammonium-dependent carbamyl phosphate synthesis (NH(3)-CPS) and the glutamine-dependent carbamyl phosphate synthesis (GLN-CPS) were increased during germination by approximately 5-and 1.7-fold respectively in the presence of 35 mm urea. The increase of NH(3)-CPS and GLN-CPS levels occurred immediately after the onset of germination and prior to ...

In a typing system based on opsonic antibodies against carbohydrate antigens of the cell envelope, 60% of Enterococcus faecalis strains can be assigned to one of four serotypes (CPS-A to CPS-D). The structural basis for enterococcal serotypes, however, is still incompletely understood. Here we demonstrate that antibodies raised against lipoteichoic acid (LTA) from a CPS-A strain are opsonic to ...

Wzc(CPS) is a tyrosine autokinase essential for the assembly of a high-molecular-weight (HMW) group 1 capsular polysaccharide (CPS) in Escherichia coli. Homologues of Wzc participate in the formation of CPS and exopolysaccharides in a variety of gram-positive and gram-negative bacteria. Phosphorylation of tyrosine residues in the Wzc(CPS) C terminus is essential for HMW CPS assembly. Overexpres...

The most intensely studied of the Vibrio vulnificus virulence factors is the capsular polysaccharide (CPS). All virulent strains produce copious amounts of CPS. Acapsular strains are avirulent. The structure of the CPS from the clinical isolate ATCC 27562 is unusual. It is serine modified and contains, surprisingly, N-acetylmuramic acid. We identified the complete 25-kb CPS biosynthesis locus f...

Cyber-Physical System (CPS) is a system of system which integrates physical system with cyber capability in order to improve the physical performance. It is being widely used in areas closely related to national economy and people's livelihood, therefore CPS security problems have drawn a global attention and an appropriate risk assessment for CPS is in urgent need. In this paper, a security fr...

Cyber-Physical Systems (CPS) tightly integrate physical and IT (cyber) worlds based on interactions between these worlds in real time. The focus of this paper is on the question how CPS can be integrated the enterprise architecture (EA) and how CPS potentially affect the EA. The approach used in this paper is to evaluate a case study from transportation showing the development of a CPS. The con...

Future generations of cyber-physical systems (CPS) engineers and scientists must be ready to tackle the increasingly complex problems facing society. While it is possible for these students to gain a theory-based CPS education from the growing CPS scientific literature, we believe, however, that theoretical understanding alone is not sufficient particularly when CPS involve complex interactions...