The potential of variable angle synchronous spectroscopy (VASS) for fluorescent mixtures resolution was assessed and compared with the rank annihilation method (RAM). For this purpose, a set of excitation-emission matrices from three standard cyclodextrin fluorescence-enhanced solutions of the pesticides aminocarb, carbendazim and coumatetralyl and a mixture of them was obtained. Careful select...

Field study was conducted to evaluate the effectiveness of formulated baits of 0.005% brodifacoum, 0.0375% coumatetralyl, 0.005% bromethalin and 2% zinc phosphide against field rats inhabiting sugarcane crop. The efficacy was calculated on the criterion of reduction in rodent activity, damaged canes and yield of harvested canes. After five applications of baits, the rodent activity reduced to 9...

The increasing prevalence of toxic substance-exposure in pets South Korea endangers the health and safety numerous companion animals, has become a cause for concern. Notably, annual incidence forensic analysis increased by more than 150% Korea, mainly populous regions such as Seoul, Incheon, Gyeonggi. In response to this growing issue, veterinary examinations were conducted on 549 dogs cats fro...

A strategic modification of acidity (pK a values) by the non-covalent host-guest interactions is one of the most promising concepts in current supramolecular chemistry. This work is aimed at enhancing the effectiveness of capillary electrophoresis (CE) in determination of pK a shifts caused by such interactions and their thermal dependencies crucial in a deep thermodynamic description. We show ...

The present study gives an overview of the in utero exposure of the developing rat fetus to Racumin rodenticide. In the current investigation, pregnant rats were exposed orally to either 1.65 or 0.83 mg/kg b.wt (1/10 and 1/20 LD50, respectively) of coumatetralyl daily on days 6 through 15 of gestation (organogenesis period). Maternal and fetal parameters were evaluated on day 20 of gestation. F...

A 55-year-old man came to the hospital with a bleeding wound on his tongue. The coating of his tongue was green, and his sputum was red. Because an increased international normalized ratio-value was measured, a blood sample was sent to our laboratory with the suspicion of coumarin intoxication. Liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) analysis confirmed the po...

BACKGROUND Emerging resistance to anticoagulant rodenticides may significantly impair house mouse (Mus musculus L.) control. As in humans and rats, sequence variants in the gene vitamin K epoxide reductase complex subunit 1 (VKORC1) of house mice are strongly implicated in the responses of mice to anticoagulants. This study gives a first overview of the distribution and frequency of such potent...

This paper describes the development of a method for the simultaneous determination of ten anticoagulant rodenticides (coumafuryl, warfarin, pindone, coumatetralyl, coumachlor, difenacoum, bromadiolone, brodifacoum, chlorophacinone and flocoumafen) in the liver and kidney based on column-switching liquid chromatography coupled with heated electrospray ionization tandem mass spectrometry. The si...

BACKGROUND Zoonotic cutaneous leishmaniasis is a growing health problem in many rural areas of Iran. Rhombomys opimus, the great gerbil, is the main animal reservoir of ZCL in the northeast and central part of Iran. The aim of the current study was to evaluate the rodenticidal effect of Coumavec® (a mixture of Coumatetralyl 0.5% and Etofenprox 0.5%) on R. opimus under laboratory condition. ME...

Anti-vitamin K drugs are widely used as anticoagulant in human thromboembolic diseases. Similar compounds have also been used as rodenticides to control rodent population since 1950s. Massive use of Wrst generation anticoagulants, especially warfarin, has lead to the development of genetic resistances in rodents. Similar resistances have been reported in human. In both cases, polymorphisms in V...