1,223 ambulant patients with gonorrhoea were each treated with a single dose of eight tablets of cotrimoxazole. 1,069 patients were followed up (794 males and 275 females). Of these, only 46 (4%) failed to respond. Cotrimoxazole in the dosage used was well tolerated by all the patients, with very few side-effects. There was clear evidence that cotrimoxazole did not mask concomitant syphilitic i...

BACKGROUND Daily prophylaxis with trimethoprim-sulfamethoxazole (cotrimoxazole) by persons with HIV reduces morbidity and mortality and is recommended by Joint United Nations Program on HIV/AIDS and World Health Organization (WHO), but there are limited published cost-effectiveness data for this intervention. We assessed the cost-effectiveness of cotrimoxazole prophylaxis for persons living wit...

Bacterial resistance has increased in the AIDS era and is attributed to the widespread use of cotrimoxazole prophylaxis against opportunistic infections in HIV/AIDS patients. In Tanzania, cotrimoxazole prophylaxis has been used for more than ten years. Little is known, however, about its impact on the spread of antibiotic resistance in HIV positive patients. This cross-sectional study was done ...

BACKGROUND Cotrimoxazole is a therapeutic option for bone-related infections but is associated to hyperkalemia and renal failure. Tolerance to this drug may reduce length of stay (LOS) and hospital charges. AIMS To evaluate renal, potassium toxicity, clinical outcome, and use of hospital resources in patients treated with cotrimoxazole for bone-related infections. METHODS Retrospective anal...

OBJECTIVES To conduct two economic analyses addressing whether to: routinely monitor HIV-infected children on antiretroviral therapy (ART) clinically or with laboratory tests; continue or stop cotrimoxazole prophylaxis when children become stabilized on ART. DESIGN AND METHODS The ARROW randomized trial investigated alternative strategies to deliver paediatric ART and cotrimoxazole prophylaxi...

TO THE EDITOR—Séraphin raised concerns regarding possible effect modification of the association between vitamin D deficiency and incidence of opportunistic infections and weight loss by receipt of cotrimoxazole prophylaxis in our recently published work [1]. In our study, the majority of participants (76%) had cotrimoxazole prescribed at antiretroviral therapy (ART) initiation because of basel...

OBJECTIVE To determine whether cotrimoxazole reduces mortality in adults receiving antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in low- and middle-income countries through a systematic review and meta-analysis. METHODS PubMed and Embase were searched for randomized controlled trials and prospective and retrospective cohort studies that compared mortality or mo...

The in-vitro action of the sulphamethoxazole/trimethoprim combination (cotrimoxazole) against coliforms, Proteus spp, and Staphylococcus aureus was re-examined. In nutrient broth the components of cotrimoxazole did not produce bacteriostatic synergy against most sulphonamide-resistant and a significant proportion of sulphonamide-sensitive strains. Any bactericidal action appeared to be due to t...

The prevalence and cotrimoxazole susceptibility of Streptococcus pneumoniae isolated from sputum of 100 HIV-positive patients attending the Nigeria Institute of Medical Research clinic was investigated using standard microbiological methods. Eleven of the sputum specimens grew Streptococcus pneumoniae. Antimicrobial susceptibility test showed that all the isolates were sensitive to amoxicillin,...