WANG classified as Papaveraceae. Aqueous extract from Corydalis tuber is known to stimulate blood circulation and relieve pain. It has traditionally been used for the treatment of neuralgia, dysmenorrhea, and gastrointestinal spasm. The analgesic and spasmolytic properties of the Corydalis tuber are essentially ascribed to several alkaloids: DL-tetrahydropalmatine (THP), D-cotydaline, and coryd...

Formalin-induced pain models were used in rats to evaluate the antinociceptive effect of the total alkaloids of Corydalis yanhusuo (TAC). The results indicated that formalin-evoked spontaneous nociceptive responses (licking behavior) could be inhibited significantly by giving (intragingival) TAC at a single dose of 150 mg/kg. Subsequently, an online comprehensive two-dimensional biochromatograp...

BACKGROUND A Chinese herb Corydalis yanhusuo W.T. Wang that showed anticancer and anti-angiogenesis effects in our previous studies was presented for further studies. In the present study, we studied the anticancer proliferation and adhesion effects of five alkaloids which were isolated from Corydalis yanhusuo. MATERIALS AND METHODS MTT dose response curves, cell migration assay, cell invasio...

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for ...

The search for analgesics with fewer side effects and less abuse potential has had limited success. A recent study identifies an analgesic alkaloid compound from Corydalis yanhusuo, a traditional Chinese medicinal herb that has a surprising mechanism of action.