Introduction: (S)- 3,5-Dihydroxyphenylglycine (DHPG) is an agonist for group I metabotropic glutamate receptors. DHPG-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. The aim of the present study was to examine the effects of DHPG superfusion on excitatory synapses on pyramidal and fast-spiking GABAergic cel...

introduction: (s)- 3,5-dihydroxyphenylglycine (dhpg) is an agonist for group i metabotropic glutamate receptors. dhpg-induced synaptic depression of excitatory synapses on hippocampal pyramidal neurons is well known model for synaptic plasticity studies. the aim of the present study was to examine the effects of dhpg superfusion on excitatory synapses on pyramidal and fast-spiking gabaergic cel...

Previous studies have demonstrated voluntary movement alterations as well motor cortex excitability and plasticity changes in patients with mild cognitive impairment (MCI). To investigate the pathophysiology of abnormalities MCI, we tested possible relationships between primary patients. Fourteen amnestic MCI (aMCI) 16 healthy controls were studied. Cognitive assessment was performed using clin...

iintroduction: repetitive transcranial magnetic stimulation (rtms) modulates the excitability of cortical neural networks. the effect of rtms on excitability of cortical networks depends on its frequency. according to the previous reports, a distinction is made between low (<1hz) and high frequencies of rtms. low frequencies of rtms inhibit seizure but high frequencies increase it. in the curre...

background: this study is the first research investigating the possible effect of pulsed power signals on the characteristics of cortical bone by comparing the mechanical properties of this type of bone pre and post expose to pulsed power. methods: a positive buck-boost converter was applied to generate adjustable high voltage, high frequency pulses (up to 500 v and 10 khz). the functional beha...

Auditory conditioning (associative learning) or focal electric stimulation of the primary auditory cortex (AC) evokes reorganization (plasticity) of the cochleotopic (frequency) map of the inferior colliculus (IC) as well as that of the AC. The reorganization results from shifts in the best frequencies (BFs) and frequency-tuning curves of single neurons. Since the importance of the cholinergic ...