background: standard methods for the measurement of myocardial perfusion are invasive and require cardiac catheterization or the use of radioisotope dyes. the coronary sinus blood flow (csbf) is an appropriate criterion for the efficacy of myocardial perfusion. this study sought to measure csbf via transthoracic echocardiography (tte) in patients with acute myocardial infarction (ami) and to as...

Adenosine release by the myocardium has been linked to a decrease in myocardial oxygen content and has been implicated in producing the concomitant increase in coronary flow. Epinephrine, norepinephrine, and histamine increase myocardial oxygen consumption and coronary flow. Nitroglycerin on the other hand, increases coronary flow but does not increase oxygen consumption. The purpose of the pre...

A 50-year-old man suffering from recurrent chest pain accompanied by transient ST-segment elevation developed spasm of the left anterior descending coronary artery after receiving ergonovine maleate. During spontaneous chest pain, thermodilution coronary sinus blood flow fell from 96 ml/min to 46 ml/min, while the coronary sinsu arteriovenous oxygen difference widened from 9.82 volumes percent ...

Ten patients with stable angina pectoris and obstructed coronary arteries (greater than 75% reduction in diameter) were studied before and during two periods of pacing, the second of which was preceded by sublingual administration of glyceryl trinitrate (mean dose 0.78 mg). Coronary sinus blood flow measurements and aortocoronary sinus blood sampling for metabolite determinations were carried o...

Coronary sinus blood flow was studied by the continuous thermodilution method in 13 subjects with normal coronary arteries and 14 patients with coronary artery disease during progressive elevation of the heart rate by atrial pacing. In 11 patients of the coronary group angina pectoris developed during pacing. In subjects with normal coronary arteries the coronary sinus blood flow rose proportio...

The secretion of atrial natriuretic peptide by the heart is not simply the arterial-coronary sinus concentration difference times coronary blood flow, because only a small fraction of total coronary blood flow passes through the atria. We measured coronary sinus and arterial plasma atrial natriuretic factor (ANF) concentrations and blood flow to each part of the heart using the radioactive micr...

The changes in the coronary circulation, which are precipitated by the acute occlusion of the coronary sinus, have been investigated. In normal animals, retrograde blood emerging from the peripheral segment of a ligated and transected circumflex coronary artery is small in quantity, and arterial in nature, signifying an insignificant interarterial collateral flow. After the coronary sinus is ar...

Twenty-one patients with various heart diseases undergoing the coronary sinus catheterization had myocardial blood flow studies before and during isometric handgrip exercise. At 30% of the maximal voluntary contraction (MVC), handgrip increased both coronary sinus blood flow by 19.8% and myocardial O2 consumption by 21.0% on the average as compared to those at rest. At 20% of MVC, the increase ...

In 14 subjects with normal coronary arteries the mean coronary sinus blood flow was 122 25 mI/min (range, 83 to 159 ml/min). The blood flow computed per 100 g of left ventricle was 82 + 16 ml/min, which is in the range of values obtained by nitrous oxide and coincidence counting methods. In 35 patients with arteriographically confirmed coronary artery disease the mean flow was similar (128 + 20...

The autoregulation of norepinephrine (NE) release mediated by presynaptic alpha and beta adrenoceptors on sympathetic nerve terminals in the heart of pentobarbital-anesthetized dog was studied. NE overflow elicited by left cardiac sympathetic nerve stimulation was determined from the coronary sinus blood, by using high-performance liquid chromatography with electrochemical detection. Intracoron...