in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...

The cytotoxic pattern of cosmetic or pharmaceutical compounds within different layers of the human cornea is of special interest with respect to ocular safety testing. The aim of this study was to evaluate the ability of a newly developed human corneal keratocyte (HCK) cell line as an in vitro model to predict toxicity towards keratocytes in the corneal stroma. The cytotoxic response of immorta...

PURPOSE Ocular surface and corneal epithelial wounds are common and potentially debilitating problems. Ideal treatments for these injuries would promote epithelial healing without inflammation, infection and scarring. In addition the best treatments would be cost-efficient, effective, non-toxic and easily applied. Histatin-1 peptides have been shown to be safe and effective enhancers of epithel...

The case is reported of a male physician who accidentally sprayed some vinblastine solution into his eyes. The resulting lesions are described.

CASE REPORT A 64 year-old female with Parkinson disease treated with amantadine for two years who suddenly suffered bilateral corneal oedema. It was initially treated as herpetic endotheliitis without improvement as we lacked information on her chronic treatment. The corneal oedema finally resolved after withdrawing the drug. DISCUSSION Amantadine hydrochloride may produce endothelial dysfunc...